Cargando…
Beyond the Isoprene Pattern: Bifunctional Polyene Cyclizations
Polyene cyclizations are capable of producing molecular complexity in a single step. While classical systems are limited to simple alkyl substitution patterns only, bifunctional polyenes take advantage of the unique reactivity of higher‐functionalized alkenes. Here, we highlight the potential of the...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336571/ https://www.ncbi.nlm.nih.gov/pubmed/33439522 http://dx.doi.org/10.1002/chem.202005157 |
_version_ | 1783733347324788736 |
---|---|
author | Feilner, Julian M. Haut, Franz‐Lucas Magauer, Thomas |
author_facet | Feilner, Julian M. Haut, Franz‐Lucas Magauer, Thomas |
author_sort | Feilner, Julian M. |
collection | PubMed |
description | Polyene cyclizations are capable of producing molecular complexity in a single step. While classical systems are limited to simple alkyl substitution patterns only, bifunctional polyenes take advantage of the unique reactivity of higher‐functionalized alkenes. Here, we highlight the potential of these variants for the synthesis of structurally complex polycycles involving unprecedented termination steps. We also want to provide a stimulus for the development of novel modes of cyclization that involve bifunctional units to enable efficient synthesis of yet inaccessible natural products. |
format | Online Article Text |
id | pubmed-8336571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83365712021-08-10 Beyond the Isoprene Pattern: Bifunctional Polyene Cyclizations Feilner, Julian M. Haut, Franz‐Lucas Magauer, Thomas Chemistry Concepts Polyene cyclizations are capable of producing molecular complexity in a single step. While classical systems are limited to simple alkyl substitution patterns only, bifunctional polyenes take advantage of the unique reactivity of higher‐functionalized alkenes. Here, we highlight the potential of these variants for the synthesis of structurally complex polycycles involving unprecedented termination steps. We also want to provide a stimulus for the development of novel modes of cyclization that involve bifunctional units to enable efficient synthesis of yet inaccessible natural products. John Wiley and Sons Inc. 2021-02-24 2021-04-26 /pmc/articles/PMC8336571/ /pubmed/33439522 http://dx.doi.org/10.1002/chem.202005157 Text en © 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Concepts Feilner, Julian M. Haut, Franz‐Lucas Magauer, Thomas Beyond the Isoprene Pattern: Bifunctional Polyene Cyclizations |
title | Beyond the Isoprene Pattern: Bifunctional Polyene Cyclizations |
title_full | Beyond the Isoprene Pattern: Bifunctional Polyene Cyclizations |
title_fullStr | Beyond the Isoprene Pattern: Bifunctional Polyene Cyclizations |
title_full_unstemmed | Beyond the Isoprene Pattern: Bifunctional Polyene Cyclizations |
title_short | Beyond the Isoprene Pattern: Bifunctional Polyene Cyclizations |
title_sort | beyond the isoprene pattern: bifunctional polyene cyclizations |
topic | Concepts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336571/ https://www.ncbi.nlm.nih.gov/pubmed/33439522 http://dx.doi.org/10.1002/chem.202005157 |
work_keys_str_mv | AT feilnerjulianm beyondtheisoprenepatternbifunctionalpolyenecyclizations AT hautfranzlucas beyondtheisoprenepatternbifunctionalpolyenecyclizations AT magauerthomas beyondtheisoprenepatternbifunctionalpolyenecyclizations |