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Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population
A polymorphism in the ADRB3 gene (Trp64Arg) has been associated with obesity, insulin resistance, and hypertension. This cross-sectional study investigated the relationships among this polymorphism, hypertension, and insulin resistance values (HOMA-IR) in 719 Japanese subjects aged 40 years and olde...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336805/ https://www.ncbi.nlm.nih.gov/pubmed/34347822 http://dx.doi.org/10.1371/journal.pone.0255444 |
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| author | Yamada, Youhei Nakamura, Haruki Tsujiguchi, Hiromasa Hara, Akinori Miyagi, Sakae Kannon, Takayuki Sato, Takehiro Hosomichi, Kazuyoshi Nguyen, Thao Thi Thu Kambayashi, Yasuhiro Shimizu, Yukari Pham, Kim Oanh Suzuki, Keita Suzuki, Fumihiko Kasahara, Tomoko Tsuboi, Hirohito Tajima, Atsushi Nakamura, Hiroyuki |
| author_facet | Yamada, Youhei Nakamura, Haruki Tsujiguchi, Hiromasa Hara, Akinori Miyagi, Sakae Kannon, Takayuki Sato, Takehiro Hosomichi, Kazuyoshi Nguyen, Thao Thi Thu Kambayashi, Yasuhiro Shimizu, Yukari Pham, Kim Oanh Suzuki, Keita Suzuki, Fumihiko Kasahara, Tomoko Tsuboi, Hirohito Tajima, Atsushi Nakamura, Hiroyuki |
| author_sort | Yamada, Youhei |
| collection | PubMed |
| description | A polymorphism in the ADRB3 gene (Trp64Arg) has been associated with obesity, insulin resistance, and hypertension. This cross-sectional study investigated the relationships among this polymorphism, hypertension, and insulin resistance values (HOMA-IR) in 719 Japanese subjects aged 40 years and older. The genotype frequencies of Trp64Trp (homozygous, wild), Trp64Arg (heterozygous, variant), and Arg64Arg (homozygous, variant) were 466 (65%), 233 (32%), and 20 (3%), respectively. Insulin resistance was associated with an increased risk of hypertension in a Japanese population. This relationship was dependent on the presence or absence of the Trp64Arg polymorphism (odds ratio, 2.054; confidence interval, 1.191 to 3.541; P value, 0.010). Therefore, the Trp64Arg polymorphism of ADRB3 was associated with hypertension and insulin resistance in a healthy Japanese population. This relationship, which was dependent on the polymorphism, may predict the development of hypertension and diabetes. |
| format | Online Article Text |
| id | pubmed-8336805 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Public Library of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-83368052021-08-05 Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population Yamada, Youhei Nakamura, Haruki Tsujiguchi, Hiromasa Hara, Akinori Miyagi, Sakae Kannon, Takayuki Sato, Takehiro Hosomichi, Kazuyoshi Nguyen, Thao Thi Thu Kambayashi, Yasuhiro Shimizu, Yukari Pham, Kim Oanh Suzuki, Keita Suzuki, Fumihiko Kasahara, Tomoko Tsuboi, Hirohito Tajima, Atsushi Nakamura, Hiroyuki PLoS One Research Article A polymorphism in the ADRB3 gene (Trp64Arg) has been associated with obesity, insulin resistance, and hypertension. This cross-sectional study investigated the relationships among this polymorphism, hypertension, and insulin resistance values (HOMA-IR) in 719 Japanese subjects aged 40 years and older. The genotype frequencies of Trp64Trp (homozygous, wild), Trp64Arg (heterozygous, variant), and Arg64Arg (homozygous, variant) were 466 (65%), 233 (32%), and 20 (3%), respectively. Insulin resistance was associated with an increased risk of hypertension in a Japanese population. This relationship was dependent on the presence or absence of the Trp64Arg polymorphism (odds ratio, 2.054; confidence interval, 1.191 to 3.541; P value, 0.010). Therefore, the Trp64Arg polymorphism of ADRB3 was associated with hypertension and insulin resistance in a healthy Japanese population. This relationship, which was dependent on the polymorphism, may predict the development of hypertension and diabetes. Public Library of Science 2021-08-04 /pmc/articles/PMC8336805/ /pubmed/34347822 http://dx.doi.org/10.1371/journal.pone.0255444 Text en © 2021 Yamada et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| spellingShingle | Research Article Yamada, Youhei Nakamura, Haruki Tsujiguchi, Hiromasa Hara, Akinori Miyagi, Sakae Kannon, Takayuki Sato, Takehiro Hosomichi, Kazuyoshi Nguyen, Thao Thi Thu Kambayashi, Yasuhiro Shimizu, Yukari Pham, Kim Oanh Suzuki, Keita Suzuki, Fumihiko Kasahara, Tomoko Tsuboi, Hirohito Tajima, Atsushi Nakamura, Hiroyuki Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population |
| title | Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population |
| title_full | Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population |
| title_fullStr | Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population |
| title_full_unstemmed | Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population |
| title_short | Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population |
| title_sort | relationships among the β3-adrenargic receptor gene trp64arg polymorphism, hypertension, and insulin resistance in a japanese population |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336805/ https://www.ncbi.nlm.nih.gov/pubmed/34347822 http://dx.doi.org/10.1371/journal.pone.0255444 |
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