Cargando…

Diffuse midline gliomas, H3 K27M-mutant are associated with less peritumoral edema and contrast enhancement in comparison to glioblastomas, H3 K27M-wildtype of midline structures

PURPOSE: The entity ‘diffuse midline glioma, H3 K27M-mutant (DMG)’ was introduced in the revised 4(th) edition of the 2016 WHO classification of brain tumors. However, there are only a few reports on magnetic resonance imaging (MRI) of these tumors. Thus, we conducted a retrospective survey focused...

Descripción completa

Detalles Bibliográficos
Autores principales: Banan, Rouzbeh, Akbarian, Arash, Samii, Majid, Samii, Amir, Bertalanffy, Helmut, Lehmann, Ulrich, Hartmann, Christian, Brüning, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336828/
https://www.ncbi.nlm.nih.gov/pubmed/34347774
http://dx.doi.org/10.1371/journal.pone.0249647
_version_ 1783733383431454720
author Banan, Rouzbeh
Akbarian, Arash
Samii, Majid
Samii, Amir
Bertalanffy, Helmut
Lehmann, Ulrich
Hartmann, Christian
Brüning, Roland
author_facet Banan, Rouzbeh
Akbarian, Arash
Samii, Majid
Samii, Amir
Bertalanffy, Helmut
Lehmann, Ulrich
Hartmann, Christian
Brüning, Roland
author_sort Banan, Rouzbeh
collection PubMed
description PURPOSE: The entity ‘diffuse midline glioma, H3 K27M-mutant (DMG)’ was introduced in the revised 4(th) edition of the 2016 WHO classification of brain tumors. However, there are only a few reports on magnetic resonance imaging (MRI) of these tumors. Thus, we conducted a retrospective survey focused on MRI features of DMG compared to midline glioblastomas H3 K27M-wildtype (mGBM-H3wt). METHODS: We identified 24 DMG cases and 19 mGBM-H3wt patients as controls. After being retrospectively evaluated for microscopic evidence of microvascular proliferations (MVP) and tumor necrosis by two experienced neuropathologists to identify the defining histological criteria of mGBM-H3wt, the samples were further analyzed by two experienced readers regarding imaging features such as shape, peritumoral edema and contrast enhancement. RESULTS: The DMG were found in the thalamus in 37.5% of cases (controls 63%), in the brainstem in 50% (vs. 32%) and spinal cord in 12.5% (vs. 5%). In MRI and considering MVP, DMG were found to be by far less likely to develop peritumoral edema (OR: 0.13; 95%-CL: 0.02–0.62) (p = 0.010). They, similarly, were associated with a significantly lower probability of developing strong contrast enhancement compared to mGBM-H3wt (OR: 0.10; 95%-CL: 0.02–0.47) (P = 0.003). CONCLUSION: Despite having highly variable imaging features, DMG exhibited markedly less edema and lower contrast enhancement in MRI compared to mGBM-H3wt. Of these features, the enhancement level was associated with evidence of MVP.
format Online
Article
Text
id pubmed-8336828
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-83368282021-08-05 Diffuse midline gliomas, H3 K27M-mutant are associated with less peritumoral edema and contrast enhancement in comparison to glioblastomas, H3 K27M-wildtype of midline structures Banan, Rouzbeh Akbarian, Arash Samii, Majid Samii, Amir Bertalanffy, Helmut Lehmann, Ulrich Hartmann, Christian Brüning, Roland PLoS One Research Article PURPOSE: The entity ‘diffuse midline glioma, H3 K27M-mutant (DMG)’ was introduced in the revised 4(th) edition of the 2016 WHO classification of brain tumors. However, there are only a few reports on magnetic resonance imaging (MRI) of these tumors. Thus, we conducted a retrospective survey focused on MRI features of DMG compared to midline glioblastomas H3 K27M-wildtype (mGBM-H3wt). METHODS: We identified 24 DMG cases and 19 mGBM-H3wt patients as controls. After being retrospectively evaluated for microscopic evidence of microvascular proliferations (MVP) and tumor necrosis by two experienced neuropathologists to identify the defining histological criteria of mGBM-H3wt, the samples were further analyzed by two experienced readers regarding imaging features such as shape, peritumoral edema and contrast enhancement. RESULTS: The DMG were found in the thalamus in 37.5% of cases (controls 63%), in the brainstem in 50% (vs. 32%) and spinal cord in 12.5% (vs. 5%). In MRI and considering MVP, DMG were found to be by far less likely to develop peritumoral edema (OR: 0.13; 95%-CL: 0.02–0.62) (p = 0.010). They, similarly, were associated with a significantly lower probability of developing strong contrast enhancement compared to mGBM-H3wt (OR: 0.10; 95%-CL: 0.02–0.47) (P = 0.003). CONCLUSION: Despite having highly variable imaging features, DMG exhibited markedly less edema and lower contrast enhancement in MRI compared to mGBM-H3wt. Of these features, the enhancement level was associated with evidence of MVP. Public Library of Science 2021-08-04 /pmc/articles/PMC8336828/ /pubmed/34347774 http://dx.doi.org/10.1371/journal.pone.0249647 Text en © 2021 Banan et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Banan, Rouzbeh
Akbarian, Arash
Samii, Majid
Samii, Amir
Bertalanffy, Helmut
Lehmann, Ulrich
Hartmann, Christian
Brüning, Roland
Diffuse midline gliomas, H3 K27M-mutant are associated with less peritumoral edema and contrast enhancement in comparison to glioblastomas, H3 K27M-wildtype of midline structures
title Diffuse midline gliomas, H3 K27M-mutant are associated with less peritumoral edema and contrast enhancement in comparison to glioblastomas, H3 K27M-wildtype of midline structures
title_full Diffuse midline gliomas, H3 K27M-mutant are associated with less peritumoral edema and contrast enhancement in comparison to glioblastomas, H3 K27M-wildtype of midline structures
title_fullStr Diffuse midline gliomas, H3 K27M-mutant are associated with less peritumoral edema and contrast enhancement in comparison to glioblastomas, H3 K27M-wildtype of midline structures
title_full_unstemmed Diffuse midline gliomas, H3 K27M-mutant are associated with less peritumoral edema and contrast enhancement in comparison to glioblastomas, H3 K27M-wildtype of midline structures
title_short Diffuse midline gliomas, H3 K27M-mutant are associated with less peritumoral edema and contrast enhancement in comparison to glioblastomas, H3 K27M-wildtype of midline structures
title_sort diffuse midline gliomas, h3 k27m-mutant are associated with less peritumoral edema and contrast enhancement in comparison to glioblastomas, h3 k27m-wildtype of midline structures
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336828/
https://www.ncbi.nlm.nih.gov/pubmed/34347774
http://dx.doi.org/10.1371/journal.pone.0249647
work_keys_str_mv AT bananrouzbeh diffusemidlinegliomash3k27mmutantareassociatedwithlessperitumoraledemaandcontrastenhancementincomparisontoglioblastomash3k27mwildtypeofmidlinestructures
AT akbarianarash diffusemidlinegliomash3k27mmutantareassociatedwithlessperitumoraledemaandcontrastenhancementincomparisontoglioblastomash3k27mwildtypeofmidlinestructures
AT samiimajid diffusemidlinegliomash3k27mmutantareassociatedwithlessperitumoraledemaandcontrastenhancementincomparisontoglioblastomash3k27mwildtypeofmidlinestructures
AT samiiamir diffusemidlinegliomash3k27mmutantareassociatedwithlessperitumoraledemaandcontrastenhancementincomparisontoglioblastomash3k27mwildtypeofmidlinestructures
AT bertalanffyhelmut diffusemidlinegliomash3k27mmutantareassociatedwithlessperitumoraledemaandcontrastenhancementincomparisontoglioblastomash3k27mwildtypeofmidlinestructures
AT lehmannulrich diffusemidlinegliomash3k27mmutantareassociatedwithlessperitumoraledemaandcontrastenhancementincomparisontoglioblastomash3k27mwildtypeofmidlinestructures
AT hartmannchristian diffusemidlinegliomash3k27mmutantareassociatedwithlessperitumoraledemaandcontrastenhancementincomparisontoglioblastomash3k27mwildtypeofmidlinestructures
AT bruningroland diffusemidlinegliomash3k27mmutantareassociatedwithlessperitumoraledemaandcontrastenhancementincomparisontoglioblastomash3k27mwildtypeofmidlinestructures