The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output

Eukaryotic initiation factor 4A-III (eIF4A3), a core helicase component of the exon junction complex, is essential for splicing, mRNA trafficking, and nonsense-mediated decay processes emerging as targets in cancer therapy. Here, we unravel eIF4A3’s tumor-promoting function by demonstrating its role...

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Detalles Bibliográficos
Autores principales: Kanellis, Dimitris C., Espinoza, Jaime A., Zisi, Asimina, Sakkas, Elpidoforos, Bartkova, Jirina, Katsori, Anna-Maria, Boström, Johan, Dyrskjøt, Lars, Broholm, Helle, Altun, Mikael, Elsässer, Simon J., Lindström, Mikael S., Bartek, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336962/
https://www.ncbi.nlm.nih.gov/pubmed/34348895
http://dx.doi.org/10.1126/sciadv.abf7561

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