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Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor—Glioma Therapy?

Tumor microenvironment (TME) is the cornerstone of the occurrence, development, invasion and diffusion of the malignant central nerve system (CNS) tumor, glioma. As the largest number of inflammatory cells in glioma TME, tumor associated macrophages (TAMs) and their secreted factors are indispensabl...

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Autores principales: Tong, Ni, He, Zhenqiang, Ma, Yujie, Wang, Zheng, Huang, Ziming, Cao, Haihong, Xu, Lanyang, Zou, Yuheng, Wang, Wanyu, Yi, Chenpeng, Yin, Zhixin, Wang, Qirui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8337013/
https://www.ncbi.nlm.nih.gov/pubmed/34368156
http://dx.doi.org/10.3389/fcell.2021.706286
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author Tong, Ni
He, Zhenqiang
Ma, Yujie
Wang, Zheng
Huang, Ziming
Cao, Haihong
Xu, Lanyang
Zou, Yuheng
Wang, Wanyu
Yi, Chenpeng
Yin, Zhixin
Wang, Qirui
author_facet Tong, Ni
He, Zhenqiang
Ma, Yujie
Wang, Zheng
Huang, Ziming
Cao, Haihong
Xu, Lanyang
Zou, Yuheng
Wang, Wanyu
Yi, Chenpeng
Yin, Zhixin
Wang, Qirui
author_sort Tong, Ni
collection PubMed
description Tumor microenvironment (TME) is the cornerstone of the occurrence, development, invasion and diffusion of the malignant central nerve system (CNS) tumor, glioma. As the largest number of inflammatory cells in glioma TME, tumor associated macrophages (TAMs) and their secreted factors are indispensable to the progression of glioma, which is a well-known immunologically “cold” tumor, including the growth of tumor cells, invasion, migration, angiogenesis, cancer immunosuppression and metabolism. TAMs intimately interface with the treatment failure and poor prognosis of glioma patients, and their density increases with increasing glioma grade. Recently, great progress has been made in TAM-targeting for anti-tumor therapy. According to TAMs’ function in tumorigenesis and progression, the major anti-tumor treatment strategies targeting TAMs are to hinder macrophage recruitment in TME, reduce TAMs viability or remodel TAMs phenotype from M2 to M1. Different approaches offer unique and effective anti-tumor effect by regulating the phagocytosis, polarization and pro-tumor behaviors of macrophages in the therapy of glioma. The present review summarizes the significant characteristics and related mechanisms of TAMs and addresses the related research progress on targeting TAMs in glioma.
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spelling pubmed-83370132021-08-05 Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor—Glioma Therapy? Tong, Ni He, Zhenqiang Ma, Yujie Wang, Zheng Huang, Ziming Cao, Haihong Xu, Lanyang Zou, Yuheng Wang, Wanyu Yi, Chenpeng Yin, Zhixin Wang, Qirui Front Cell Dev Biol Cell and Developmental Biology Tumor microenvironment (TME) is the cornerstone of the occurrence, development, invasion and diffusion of the malignant central nerve system (CNS) tumor, glioma. As the largest number of inflammatory cells in glioma TME, tumor associated macrophages (TAMs) and their secreted factors are indispensable to the progression of glioma, which is a well-known immunologically “cold” tumor, including the growth of tumor cells, invasion, migration, angiogenesis, cancer immunosuppression and metabolism. TAMs intimately interface with the treatment failure and poor prognosis of glioma patients, and their density increases with increasing glioma grade. Recently, great progress has been made in TAM-targeting for anti-tumor therapy. According to TAMs’ function in tumorigenesis and progression, the major anti-tumor treatment strategies targeting TAMs are to hinder macrophage recruitment in TME, reduce TAMs viability or remodel TAMs phenotype from M2 to M1. Different approaches offer unique and effective anti-tumor effect by regulating the phagocytosis, polarization and pro-tumor behaviors of macrophages in the therapy of glioma. The present review summarizes the significant characteristics and related mechanisms of TAMs and addresses the related research progress on targeting TAMs in glioma. Frontiers Media S.A. 2021-07-21 /pmc/articles/PMC8337013/ /pubmed/34368156 http://dx.doi.org/10.3389/fcell.2021.706286 Text en Copyright © 2021 Tong, He, Ma, Wang, Huang, Cao, Xu, Zou, Wang, Yi, Yin and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Tong, Ni
He, Zhenqiang
Ma, Yujie
Wang, Zheng
Huang, Ziming
Cao, Haihong
Xu, Lanyang
Zou, Yuheng
Wang, Wanyu
Yi, Chenpeng
Yin, Zhixin
Wang, Qirui
Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor—Glioma Therapy?
title Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor—Glioma Therapy?
title_full Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor—Glioma Therapy?
title_fullStr Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor—Glioma Therapy?
title_full_unstemmed Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor—Glioma Therapy?
title_short Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor—Glioma Therapy?
title_sort tumor associated macrophages, as the dominant immune cells, are an indispensable target for immunologically cold tumor—glioma therapy?
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8337013/
https://www.ncbi.nlm.nih.gov/pubmed/34368156
http://dx.doi.org/10.3389/fcell.2021.706286
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