Drug-Induced Liver Injury From Enobosarm (Ostarine), a Selective Androgen Receptor Modulator

Anabolic steroids are well-known to cause liver injury, which may manifest with jaundice and elevated liver enzymes. Selective androgen receptor modulators (SARMs) have been developed to enhance muscle bulk without the side effects associated with exogenous androgen steroids. We report a case of sig...

Descripción completa

Detalles Bibliográficos
Autores principales: Bedi, Harjot, Hammond, Carl, Sanders, David, Yang, Hui-Min, Yoshida, Eric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8337042/
https://www.ncbi.nlm.nih.gov/pubmed/34368386
http://dx.doi.org/10.14309/crj.0000000000000518
_version_ 1783733429514272768
author Bedi, Harjot
Hammond, Carl
Sanders, David
Yang, Hui-Min
Yoshida, Eric M.
author_facet Bedi, Harjot
Hammond, Carl
Sanders, David
Yang, Hui-Min
Yoshida, Eric M.
author_sort Bedi, Harjot
collection PubMed
description Anabolic steroids are well-known to cause liver injury, which may manifest with jaundice and elevated liver enzymes. Selective androgen receptor modulators (SARMs) have been developed to enhance muscle bulk without the side effects associated with exogenous androgen steroids. We report a case of significant cholestatic liver injury associated with a SARM, ostarine (enobosarm), similar to that associated with anabolic steroids. Liver injury from SARMs has not been reported frequently, and we speculate that this may be seen more often as the consumption of SARMs increases in the athletic market.
format Online
Article
Text
id pubmed-8337042
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Wolters Kluwer
record_format MEDLINE/PubMed
spelling pubmed-83370422021-08-05 Drug-Induced Liver Injury From Enobosarm (Ostarine), a Selective Androgen Receptor Modulator Bedi, Harjot Hammond, Carl Sanders, David Yang, Hui-Min Yoshida, Eric M. ACG Case Rep J Case Report Anabolic steroids are well-known to cause liver injury, which may manifest with jaundice and elevated liver enzymes. Selective androgen receptor modulators (SARMs) have been developed to enhance muscle bulk without the side effects associated with exogenous androgen steroids. We report a case of significant cholestatic liver injury associated with a SARM, ostarine (enobosarm), similar to that associated with anabolic steroids. Liver injury from SARMs has not been reported frequently, and we speculate that this may be seen more often as the consumption of SARMs increases in the athletic market. Wolters Kluwer 2021-01-07 /pmc/articles/PMC8337042/ /pubmed/34368386 http://dx.doi.org/10.14309/crj.0000000000000518 Text en © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Bedi, Harjot
Hammond, Carl
Sanders, David
Yang, Hui-Min
Yoshida, Eric M.
Drug-Induced Liver Injury From Enobosarm (Ostarine), a Selective Androgen Receptor Modulator
title Drug-Induced Liver Injury From Enobosarm (Ostarine), a Selective Androgen Receptor Modulator
title_full Drug-Induced Liver Injury From Enobosarm (Ostarine), a Selective Androgen Receptor Modulator
title_fullStr Drug-Induced Liver Injury From Enobosarm (Ostarine), a Selective Androgen Receptor Modulator
title_full_unstemmed Drug-Induced Liver Injury From Enobosarm (Ostarine), a Selective Androgen Receptor Modulator
title_short Drug-Induced Liver Injury From Enobosarm (Ostarine), a Selective Androgen Receptor Modulator
title_sort drug-induced liver injury from enobosarm (ostarine), a selective androgen receptor modulator
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8337042/
https://www.ncbi.nlm.nih.gov/pubmed/34368386
http://dx.doi.org/10.14309/crj.0000000000000518
work_keys_str_mv AT bediharjot druginducedliverinjuryfromenobosarmostarineaselectiveandrogenreceptormodulator
AT hammondcarl druginducedliverinjuryfromenobosarmostarineaselectiveandrogenreceptormodulator
AT sandersdavid druginducedliverinjuryfromenobosarmostarineaselectiveandrogenreceptormodulator
AT yanghuimin druginducedliverinjuryfromenobosarmostarineaselectiveandrogenreceptormodulator
AT yoshidaericm druginducedliverinjuryfromenobosarmostarineaselectiveandrogenreceptormodulator

Ejemplares similares