Combination Treatment of CI-994 With Etoposide Potentiates Anticancer Effects Through a Topoisomerase II-Dependent Mechanism in Atypical Teratoid/Rhabdoid Tumor (AT/RT)

PURPOSE: Atypical teratoid/rhabdoid tumor (AT/RT) is arising typically in young children and is associated with a dismal prognosis which there is currently no curative chemotherapeutic regimen. Based on previous studies showing high histone deacetylase 1 (HDAC1) expression in AT/RT, the HDAC1 inhibi...

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Detalles Bibliográficos
Autores principales: Kim, Hee Yeon, Choi, Seung Ah, Koh, Eun Jung, Kim, Kyung Hyun, Phi, Ji Hoon, Lee, Ji Yeoun, Kim, Seung-Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8337050/
https://www.ncbi.nlm.nih.gov/pubmed/34367950
http://dx.doi.org/10.3389/fonc.2021.648023

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