Determination of Alkaloids and Flavonoids in Sophora flavescens by UHPLC-Q-TOF/MS

This study is based on UHPLC-Q-TOF/MS and fragment ions to achieve classification and identification of alkaloids and flavonoids in Sophora flavescens. By reviewing the available and relevant literature, the mass fragmentation rules of alkaloids and flavonoids were summarized. 0.1% formic acid water...

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Autores principales: Dong, Yaqian, Jia, Guoxiang, Hu, Jingwen, Liu, Hui, Wu, Tingting, Yang, Shenshen, Li, Yubo, Cai, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8337118/
https://www.ncbi.nlm.nih.gov/pubmed/34367714
http://dx.doi.org/10.1155/2021/9915027
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author Dong, Yaqian
Jia, Guoxiang
Hu, Jingwen
Liu, Hui
Wu, Tingting
Yang, Shenshen
Li, Yubo
Cai, Ting
author_facet Dong, Yaqian
Jia, Guoxiang
Hu, Jingwen
Liu, Hui
Wu, Tingting
Yang, Shenshen
Li, Yubo
Cai, Ting
author_sort Dong, Yaqian
collection PubMed
description This study is based on UHPLC-Q-TOF/MS and fragment ions to achieve classification and identification of alkaloids and flavonoids in Sophora flavescens. By reviewing the available and relevant literature, the mass fragmentation rules of alkaloids and flavonoids were summarized. 0.1% formic acid water (A) and acetonitrile (B) were used as mobile phases. 37 chemical constituents were identified, including 13 alkaloids and 24 flavonoids. This research method offers a complete strategy based on the fragmentation information of characteristic fragment ions and neutral loss obtained by MS/MS to characterize the chemical composition of Sophora flavescens.
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spelling pubmed-83371182021-08-05 Determination of Alkaloids and Flavonoids in Sophora flavescens by UHPLC-Q-TOF/MS Dong, Yaqian Jia, Guoxiang Hu, Jingwen Liu, Hui Wu, Tingting Yang, Shenshen Li, Yubo Cai, Ting J Anal Methods Chem Research Article This study is based on UHPLC-Q-TOF/MS and fragment ions to achieve classification and identification of alkaloids and flavonoids in Sophora flavescens. By reviewing the available and relevant literature, the mass fragmentation rules of alkaloids and flavonoids were summarized. 0.1% formic acid water (A) and acetonitrile (B) were used as mobile phases. 37 chemical constituents were identified, including 13 alkaloids and 24 flavonoids. This research method offers a complete strategy based on the fragmentation information of characteristic fragment ions and neutral loss obtained by MS/MS to characterize the chemical composition of Sophora flavescens. Hindawi 2021-07-28 /pmc/articles/PMC8337118/ /pubmed/34367714 http://dx.doi.org/10.1155/2021/9915027 Text en Copyright © 2021 Yaqian Dong et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dong, Yaqian
Jia, Guoxiang
Hu, Jingwen
Liu, Hui
Wu, Tingting
Yang, Shenshen
Li, Yubo
Cai, Ting
Determination of Alkaloids and Flavonoids in Sophora flavescens by UHPLC-Q-TOF/MS
title Determination of Alkaloids and Flavonoids in Sophora flavescens by UHPLC-Q-TOF/MS
title_full Determination of Alkaloids and Flavonoids in Sophora flavescens by UHPLC-Q-TOF/MS
title_fullStr Determination of Alkaloids and Flavonoids in Sophora flavescens by UHPLC-Q-TOF/MS
title_full_unstemmed Determination of Alkaloids and Flavonoids in Sophora flavescens by UHPLC-Q-TOF/MS
title_short Determination of Alkaloids and Flavonoids in Sophora flavescens by UHPLC-Q-TOF/MS
title_sort determination of alkaloids and flavonoids in sophora flavescens by uhplc-q-tof/ms
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8337118/
https://www.ncbi.nlm.nih.gov/pubmed/34367714
http://dx.doi.org/10.1155/2021/9915027
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