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Dynamics of Tuberculosis (TB) with Drug Resistance to First-Line Treatment and Leaky Vaccination: A Deterministic Modelling Perspective
A deterministic model was formulated and employed in the analysis of the dynamics of tuberculosis with a keen emphasis on vaccination and drug resistance as the first line of treatment. It was assumed that some of the susceptible population were vaccinated but with temporal immunity. This is due to...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8337137/ https://www.ncbi.nlm.nih.gov/pubmed/34367319 http://dx.doi.org/10.1155/2021/5593864 |
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author | Otoo, Dominic Osman, Shaibu Poku, Stephen Atta Donkoh, Elvis Kobina |
author_facet | Otoo, Dominic Osman, Shaibu Poku, Stephen Atta Donkoh, Elvis Kobina |
author_sort | Otoo, Dominic |
collection | PubMed |
description | A deterministic model was formulated and employed in the analysis of the dynamics of tuberculosis with a keen emphasis on vaccination and drug resistance as the first line of treatment. It was assumed that some of the susceptible population were vaccinated but with temporal immunity. This is due to the fact that vaccines do not confer permanent immunity. Moreover, part of the infected individual after treatment grows resistance to the drug. Infective immigrants were also considered to be part of the population. The basic reproductive number for the model is estimated using the next-generation matrix method. The equilibrium points of the TB model and their local and global stability were determined. It was established that if the basic reproductive number was less than unity (R(0) < 1), then the disease free equilibrium is stable and unstable if R(0) > 1. Furthermore, we investigated the optimal prevention, treatment, and vaccination as control measures for the disease. As the objective functional was optimised, there have been a significant reduction in the number of infections and an increase in the number of recovery. The best control measure in combating tuberculosis infections is prevention and vaccination of the susceptible population. |
format | Online Article Text |
id | pubmed-8337137 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-83371372021-08-05 Dynamics of Tuberculosis (TB) with Drug Resistance to First-Line Treatment and Leaky Vaccination: A Deterministic Modelling Perspective Otoo, Dominic Osman, Shaibu Poku, Stephen Atta Donkoh, Elvis Kobina Comput Math Methods Med Research Article A deterministic model was formulated and employed in the analysis of the dynamics of tuberculosis with a keen emphasis on vaccination and drug resistance as the first line of treatment. It was assumed that some of the susceptible population were vaccinated but with temporal immunity. This is due to the fact that vaccines do not confer permanent immunity. Moreover, part of the infected individual after treatment grows resistance to the drug. Infective immigrants were also considered to be part of the population. The basic reproductive number for the model is estimated using the next-generation matrix method. The equilibrium points of the TB model and their local and global stability were determined. It was established that if the basic reproductive number was less than unity (R(0) < 1), then the disease free equilibrium is stable and unstable if R(0) > 1. Furthermore, we investigated the optimal prevention, treatment, and vaccination as control measures for the disease. As the objective functional was optimised, there have been a significant reduction in the number of infections and an increase in the number of recovery. The best control measure in combating tuberculosis infections is prevention and vaccination of the susceptible population. Hindawi 2021-07-27 /pmc/articles/PMC8337137/ /pubmed/34367319 http://dx.doi.org/10.1155/2021/5593864 Text en Copyright © 2021 Dominic Otoo et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Otoo, Dominic Osman, Shaibu Poku, Stephen Atta Donkoh, Elvis Kobina Dynamics of Tuberculosis (TB) with Drug Resistance to First-Line Treatment and Leaky Vaccination: A Deterministic Modelling Perspective |
title | Dynamics of Tuberculosis (TB) with Drug Resistance to First-Line Treatment and Leaky Vaccination: A Deterministic Modelling Perspective |
title_full | Dynamics of Tuberculosis (TB) with Drug Resistance to First-Line Treatment and Leaky Vaccination: A Deterministic Modelling Perspective |
title_fullStr | Dynamics of Tuberculosis (TB) with Drug Resistance to First-Line Treatment and Leaky Vaccination: A Deterministic Modelling Perspective |
title_full_unstemmed | Dynamics of Tuberculosis (TB) with Drug Resistance to First-Line Treatment and Leaky Vaccination: A Deterministic Modelling Perspective |
title_short | Dynamics of Tuberculosis (TB) with Drug Resistance to First-Line Treatment and Leaky Vaccination: A Deterministic Modelling Perspective |
title_sort | dynamics of tuberculosis (tb) with drug resistance to first-line treatment and leaky vaccination: a deterministic modelling perspective |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8337137/ https://www.ncbi.nlm.nih.gov/pubmed/34367319 http://dx.doi.org/10.1155/2021/5593864 |
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