Sustained effects of rapidly-acting antidepressants require BDNF-dependent MeCP2 phosphorylation

The rapidly acting antidepressants ketamine and scopolamine exert behavioral effects that can last several days to weeks in some patients. The molecular mechanisms underlying the maintenance of these antidepressant effects are unknown. Here, we show that methyl-CpG-binding protein 2 (MeCP2) phosphor...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Ji-Woon, Autry, Anita E., Na, Elisa S., Adachi, Megumi, Bjorkholm, Carl, Kavalali, Ege T., Monteggia, Lisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338784/
https://www.ncbi.nlm.nih.gov/pubmed/34183865
http://dx.doi.org/10.1038/s41593-021-00868-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338784/
https://www.ncbi.nlm.nih.gov/pubmed/34183865
http://dx.doi.org/10.1038/s41593-021-00868-8

Ejemplares similares