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Prevention of postoperative intrapericardial adhesion by dextrin hydrogel

OBJECTIVE: Postoperative intrapericardial adhesion increases the risk of complications in patients undergoing reoperation. We investigated the effect of a bioabsorbable dextrin hydrogel (DHG) on the formation of intrapericardial adhesions. METHODS: Intrapericardial adhesion was surgically induced in...

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Autores principales: Kikusaki, Satoshi, Takagi, Kazuyoshi, Shojima, Takahiro, Saku, Kosuke, Fukuda, Tomofumi, Oryoji, Atsunobu, Anegawa, Tomoyuki, Fukumoto, Yoshihiro, Aoki, Hiroki, Tanaka, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338828/
https://www.ncbi.nlm.nih.gov/pubmed/33417187
http://dx.doi.org/10.1007/s11748-020-01581-2
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author Kikusaki, Satoshi
Takagi, Kazuyoshi
Shojima, Takahiro
Saku, Kosuke
Fukuda, Tomofumi
Oryoji, Atsunobu
Anegawa, Tomoyuki
Fukumoto, Yoshihiro
Aoki, Hiroki
Tanaka, Hiroyuki
author_facet Kikusaki, Satoshi
Takagi, Kazuyoshi
Shojima, Takahiro
Saku, Kosuke
Fukuda, Tomofumi
Oryoji, Atsunobu
Anegawa, Tomoyuki
Fukumoto, Yoshihiro
Aoki, Hiroki
Tanaka, Hiroyuki
author_sort Kikusaki, Satoshi
collection PubMed
description OBJECTIVE: Postoperative intrapericardial adhesion increases the risk of complications in patients undergoing reoperation. We investigated the effect of a bioabsorbable dextrin hydrogel (DHG) on the formation of intrapericardial adhesions. METHODS: Intrapericardial adhesion was surgically induced in Japanese white rabbits with DHG treatment (Adh + DHG) or without DHG treatment (Adh). The sham group was not treated with DHG and intrapericardial adhesion was not induced. The extent of intrapericardial adhesion was assessed by adhesion scoring and crystal violet staining of the pericardial cavity. Bromodeoxyuridine (BrdU) uptake assay was performed to assess the proliferative response to the injury in the tissue beneath the intrapericardial adhesion. RESULTS: The Adh + DHG group showed looser intrapericardial adhesions compared to the Adh group. The adhesion area of the Adh + DHG group was 4.6 ± 2.2%, whereas that of the Adh group was 32.6 ± 6.4% at the end of the 28-day observation period (p < 0.01). The induction of intrapericardial adhesion resulted in a proliferative response mainly in the cardiac tissue just beneath the adhesion. There were 48.6 ± 10.7 cells/0.1 mm(2) BrdU-positive cells in the Adh + DHG group and 135.7 ± 23.8 cells/0.1 mm(2) BrdU-positive cells in the Adh group on day 28 (p < 0.05). CONCLUSION: These findings indicate that DHG effectively prevented intrapericardial adhesion in this model.
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spelling pubmed-83388282021-08-20 Prevention of postoperative intrapericardial adhesion by dextrin hydrogel Kikusaki, Satoshi Takagi, Kazuyoshi Shojima, Takahiro Saku, Kosuke Fukuda, Tomofumi Oryoji, Atsunobu Anegawa, Tomoyuki Fukumoto, Yoshihiro Aoki, Hiroki Tanaka, Hiroyuki Gen Thorac Cardiovasc Surg Original Article OBJECTIVE: Postoperative intrapericardial adhesion increases the risk of complications in patients undergoing reoperation. We investigated the effect of a bioabsorbable dextrin hydrogel (DHG) on the formation of intrapericardial adhesions. METHODS: Intrapericardial adhesion was surgically induced in Japanese white rabbits with DHG treatment (Adh + DHG) or without DHG treatment (Adh). The sham group was not treated with DHG and intrapericardial adhesion was not induced. The extent of intrapericardial adhesion was assessed by adhesion scoring and crystal violet staining of the pericardial cavity. Bromodeoxyuridine (BrdU) uptake assay was performed to assess the proliferative response to the injury in the tissue beneath the intrapericardial adhesion. RESULTS: The Adh + DHG group showed looser intrapericardial adhesions compared to the Adh group. The adhesion area of the Adh + DHG group was 4.6 ± 2.2%, whereas that of the Adh group was 32.6 ± 6.4% at the end of the 28-day observation period (p < 0.01). The induction of intrapericardial adhesion resulted in a proliferative response mainly in the cardiac tissue just beneath the adhesion. There were 48.6 ± 10.7 cells/0.1 mm(2) BrdU-positive cells in the Adh + DHG group and 135.7 ± 23.8 cells/0.1 mm(2) BrdU-positive cells in the Adh group on day 28 (p < 0.05). CONCLUSION: These findings indicate that DHG effectively prevented intrapericardial adhesion in this model. Springer Singapore 2021-01-08 2021 /pmc/articles/PMC8338828/ /pubmed/33417187 http://dx.doi.org/10.1007/s11748-020-01581-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Kikusaki, Satoshi
Takagi, Kazuyoshi
Shojima, Takahiro
Saku, Kosuke
Fukuda, Tomofumi
Oryoji, Atsunobu
Anegawa, Tomoyuki
Fukumoto, Yoshihiro
Aoki, Hiroki
Tanaka, Hiroyuki
Prevention of postoperative intrapericardial adhesion by dextrin hydrogel
title Prevention of postoperative intrapericardial adhesion by dextrin hydrogel
title_full Prevention of postoperative intrapericardial adhesion by dextrin hydrogel
title_fullStr Prevention of postoperative intrapericardial adhesion by dextrin hydrogel
title_full_unstemmed Prevention of postoperative intrapericardial adhesion by dextrin hydrogel
title_short Prevention of postoperative intrapericardial adhesion by dextrin hydrogel
title_sort prevention of postoperative intrapericardial adhesion by dextrin hydrogel
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338828/
https://www.ncbi.nlm.nih.gov/pubmed/33417187
http://dx.doi.org/10.1007/s11748-020-01581-2
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