Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation

A robust breast cancer prevention strategy requires risk assessment biomarkers for early detection. We show that expression of ELF5, a transcription factor critical for normal mammary development, is downregulated in mammary luminal epithelia with age. DNA methylation of the ELF5 promoter is negativ...

Descripción completa

Detalles Bibliográficos
Autores principales: Miyano, Masaru, Sayaman, Rosalyn W., Shalabi, Sundus F., Senapati, Parijat, Lopez, Jennifer C., Angarola, Brittany Lynn, Hinz, Stefan, Zirbes, Arrianna, Anczukow, Olga, Yee, Lisa D., Sedrak, Mina S., Stampfer, Martha R., Seewaldt, Victoria L., LaBarge, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338914/
https://www.ncbi.nlm.nih.gov/pubmed/34140348
http://dx.doi.org/10.1158/1940-6207.CAPR-20-0635

Ejemplares similares

Ejemplares similares