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A proteomic platform to identify off-target proteins associated with therapeutic modalities that induce protein degradation or gene silencing
Novel modalities such as PROTAC and RNAi have the ability to inadvertently alter the abundance of endogenous proteins. Currently available in vitro secondary pharmacology assays, which evaluate off-target binding or activity of small molecules, do not fully assess the off-target effects of PROTAC an...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338952/ https://www.ncbi.nlm.nih.gov/pubmed/34349202 http://dx.doi.org/10.1038/s41598-021-95354-3 |