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Transcriptomic profile of cationic channels in human pulmonary arterial hypertension
The dysregulation of K(+) channels is a hallmark of pulmonary arterial hypertension (PAH). Herein, the channelome was analyzed in lungs of patients with PAH in a public transcriptomic database. Sixty six (46%) mRNA encoding cationic channels were dysregulated in PAH with most of them downregulated (...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338963/ https://www.ncbi.nlm.nih.gov/pubmed/34349187 http://dx.doi.org/10.1038/s41598-021-95196-z |
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author | Perez-Vizcaino, Francisco Cogolludo, Angel Mondejar-Parreño, Gema |
author_facet | Perez-Vizcaino, Francisco Cogolludo, Angel Mondejar-Parreño, Gema |
author_sort | Perez-Vizcaino, Francisco |
collection | PubMed |
description | The dysregulation of K(+) channels is a hallmark of pulmonary arterial hypertension (PAH). Herein, the channelome was analyzed in lungs of patients with PAH in a public transcriptomic database. Sixty six (46%) mRNA encoding cationic channels were dysregulated in PAH with most of them downregulated (83%). The principal component analysis indicated that dysregulated cationic channel expression is a signature of the disease. Changes were very similar in idiopathic, connective tissue disease and congenital heart disease associated PAH. This analysis 1) is in agreement with the widely recognized pathophysiological role of TASK1 and K(V)1.5, 2) supports previous preliminary reports pointing to the dysregulation of several K(+) channels including the downregulation of K(V)1.1, K(V)1.4, K(V)1.6, K(V)7.1, K(V)7.4, K(V)9.3 and TWIK2 and the upregulation of K(Ca)1.1 and 3) points to other cationic channels dysregulated such as Kv7.3, TALK2, Ca(V)1 and TRPV4 which might play a pathophysiological role in PAH. The significance of other changes found in Na(+) and TRP channels remains to be investigated. |
format | Online Article Text |
id | pubmed-8338963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-83389632021-08-05 Transcriptomic profile of cationic channels in human pulmonary arterial hypertension Perez-Vizcaino, Francisco Cogolludo, Angel Mondejar-Parreño, Gema Sci Rep Article The dysregulation of K(+) channels is a hallmark of pulmonary arterial hypertension (PAH). Herein, the channelome was analyzed in lungs of patients with PAH in a public transcriptomic database. Sixty six (46%) mRNA encoding cationic channels were dysregulated in PAH with most of them downregulated (83%). The principal component analysis indicated that dysregulated cationic channel expression is a signature of the disease. Changes were very similar in idiopathic, connective tissue disease and congenital heart disease associated PAH. This analysis 1) is in agreement with the widely recognized pathophysiological role of TASK1 and K(V)1.5, 2) supports previous preliminary reports pointing to the dysregulation of several K(+) channels including the downregulation of K(V)1.1, K(V)1.4, K(V)1.6, K(V)7.1, K(V)7.4, K(V)9.3 and TWIK2 and the upregulation of K(Ca)1.1 and 3) points to other cationic channels dysregulated such as Kv7.3, TALK2, Ca(V)1 and TRPV4 which might play a pathophysiological role in PAH. The significance of other changes found in Na(+) and TRP channels remains to be investigated. Nature Publishing Group UK 2021-08-04 /pmc/articles/PMC8338963/ /pubmed/34349187 http://dx.doi.org/10.1038/s41598-021-95196-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Perez-Vizcaino, Francisco Cogolludo, Angel Mondejar-Parreño, Gema Transcriptomic profile of cationic channels in human pulmonary arterial hypertension |
title | Transcriptomic profile of cationic channels in human pulmonary arterial hypertension |
title_full | Transcriptomic profile of cationic channels in human pulmonary arterial hypertension |
title_fullStr | Transcriptomic profile of cationic channels in human pulmonary arterial hypertension |
title_full_unstemmed | Transcriptomic profile of cationic channels in human pulmonary arterial hypertension |
title_short | Transcriptomic profile of cationic channels in human pulmonary arterial hypertension |
title_sort | transcriptomic profile of cationic channels in human pulmonary arterial hypertension |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338963/ https://www.ncbi.nlm.nih.gov/pubmed/34349187 http://dx.doi.org/10.1038/s41598-021-95196-z |
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