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Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer’s disease

Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder. Increased Aβ production plays a fundamental role in the pathogenesis of the disease and BACE1, the protease that triggers the amyloidogenic processing of APP, is a key protein and a pharmacological target in AD. Chan...

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Detalles Bibliográficos
Autores principales:	Bettegazzi, Barbara, Sebastian Monasor, Laura, Bellani, Serena, Codazzi, Franca, Restelli, Lisa Michelle, Colombo, Alessio Vittorio, Deigendesch, Nikolaus, Frank, Stephan, Saito, Takashi, Saido, Takaomi C., Lammich, Sven, Tahirovic, Sabina, Grohovaz, Fabio, Zacchetti, Daniele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339060/ https://www.ncbi.nlm.nih.gov/pubmed/34349120 http://dx.doi.org/10.1038/s41419-021-04062-3

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