SCLC-J1, a novel small cell lung cancer cell line

Small cell lung cancer (SCLC) is a type of high-grade neuroendocrine carcinoma. It initially responds to chemotherapy but rapidly becomes chemoresistant and it is highly proliferative. The prognosis in SCLC is poor. We have established a novel SCLC cell line, SCLC-J1, from a malignant pleural effusi...

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Autores principales: Ohara, Kazuo, Kinoshita, Shintaro, Ando, Jun, Azusawa, Yoko, Ishii, Midori, Harada, Sakiko, Mitsuishi, Yoichiro, Asao, Tetsuhiko, Tajima, Ken, Yamamoto, Taketsugu, Takahashi, Fumiyuki, Komatsu, Norio, Takahashi, Kazuhisa, Ando, Miki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339127/
https://www.ncbi.nlm.nih.gov/pubmed/34381882
http://dx.doi.org/10.1016/j.bbrep.2021.101089
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author Ohara, Kazuo
Kinoshita, Shintaro
Ando, Jun
Azusawa, Yoko
Ishii, Midori
Harada, Sakiko
Mitsuishi, Yoichiro
Asao, Tetsuhiko
Tajima, Ken
Yamamoto, Taketsugu
Takahashi, Fumiyuki
Komatsu, Norio
Takahashi, Kazuhisa
Ando, Miki
author_facet Ohara, Kazuo
Kinoshita, Shintaro
Ando, Jun
Azusawa, Yoko
Ishii, Midori
Harada, Sakiko
Mitsuishi, Yoichiro
Asao, Tetsuhiko
Tajima, Ken
Yamamoto, Taketsugu
Takahashi, Fumiyuki
Komatsu, Norio
Takahashi, Kazuhisa
Ando, Miki
author_sort Ohara, Kazuo
collection PubMed
description Small cell lung cancer (SCLC) is a type of high-grade neuroendocrine carcinoma. It initially responds to chemotherapy but rapidly becomes chemoresistant and it is highly proliferative. The prognosis in SCLC is poor. We have established a novel SCLC cell line, SCLC-J1, from a malignant pleural effusion in a patient with advanced SCLC. SCLC-J1 cells express ganglioside GD2, CD276, and Delta-like protein 3. RB1 is lost. These features of the new SCLC cell line may be useful in understanding the cellular and molecular biology of SCLC and in designing better treatment.
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spelling pubmed-83391272021-08-10 SCLC-J1, a novel small cell lung cancer cell line Ohara, Kazuo Kinoshita, Shintaro Ando, Jun Azusawa, Yoko Ishii, Midori Harada, Sakiko Mitsuishi, Yoichiro Asao, Tetsuhiko Tajima, Ken Yamamoto, Taketsugu Takahashi, Fumiyuki Komatsu, Norio Takahashi, Kazuhisa Ando, Miki Biochem Biophys Rep Research Article Small cell lung cancer (SCLC) is a type of high-grade neuroendocrine carcinoma. It initially responds to chemotherapy but rapidly becomes chemoresistant and it is highly proliferative. The prognosis in SCLC is poor. We have established a novel SCLC cell line, SCLC-J1, from a malignant pleural effusion in a patient with advanced SCLC. SCLC-J1 cells express ganglioside GD2, CD276, and Delta-like protein 3. RB1 is lost. These features of the new SCLC cell line may be useful in understanding the cellular and molecular biology of SCLC and in designing better treatment. Elsevier 2021-07-28 /pmc/articles/PMC8339127/ /pubmed/34381882 http://dx.doi.org/10.1016/j.bbrep.2021.101089 Text en © 2021 Juntendo University School of Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Ohara, Kazuo
Kinoshita, Shintaro
Ando, Jun
Azusawa, Yoko
Ishii, Midori
Harada, Sakiko
Mitsuishi, Yoichiro
Asao, Tetsuhiko
Tajima, Ken
Yamamoto, Taketsugu
Takahashi, Fumiyuki
Komatsu, Norio
Takahashi, Kazuhisa
Ando, Miki
SCLC-J1, a novel small cell lung cancer cell line
title SCLC-J1, a novel small cell lung cancer cell line
title_full SCLC-J1, a novel small cell lung cancer cell line
title_fullStr SCLC-J1, a novel small cell lung cancer cell line
title_full_unstemmed SCLC-J1, a novel small cell lung cancer cell line
title_short SCLC-J1, a novel small cell lung cancer cell line
title_sort sclc-j1, a novel small cell lung cancer cell line
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339127/
https://www.ncbi.nlm.nih.gov/pubmed/34381882
http://dx.doi.org/10.1016/j.bbrep.2021.101089
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