Deficiency of peroxisome proliferator-activated receptor α attenuates apoptosis and promotes migration of vascular smooth muscle cells

Peroxisome proliferator-activated receptor (PPAR) α is widely expressed in the vasculature and has pleiotropic and lipid-lowering independent effects, but its role in the growth and function of vascular smooth muscle cells (VSMCs) during vascular pathophysiology is still unclear. Herein, VSMC-specif...

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Autores principales: Duan, Yan, Qi, Dan, Liu, Ye, Song, Yanting, Wang, Xia, Jiao, Shiyu, Li, Huihua, Gonzalez, Frank J., Qi, Yongfen, Xu, Qingbo, Du, Jie, Qu, Aijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339143/
https://www.ncbi.nlm.nih.gov/pubmed/34381883
http://dx.doi.org/10.1016/j.bbrep.2021.101091
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author Duan, Yan
Qi, Dan
Liu, Ye
Song, Yanting
Wang, Xia
Jiao, Shiyu
Li, Huihua
Gonzalez, Frank J.
Qi, Yongfen
Xu, Qingbo
Du, Jie
Qu, Aijuan
author_facet Duan, Yan
Qi, Dan
Liu, Ye
Song, Yanting
Wang, Xia
Jiao, Shiyu
Li, Huihua
Gonzalez, Frank J.
Qi, Yongfen
Xu, Qingbo
Du, Jie
Qu, Aijuan
author_sort Duan, Yan
collection PubMed
description Peroxisome proliferator-activated receptor (PPAR) α is widely expressed in the vasculature and has pleiotropic and lipid-lowering independent effects, but its role in the growth and function of vascular smooth muscle cells (VSMCs) during vascular pathophysiology is still unclear. Herein, VSMC-specific PPARα-deficient mice (Ppara(ΔSMC)) were generated by Cre-LoxP site-specific recombinase technology and VSMCs were isolated from mice aorta. PPARα deficiency attenuated VSMC apoptosis induced by angiotensin (Ang) II and hydrogen peroxide, and increased the migration of Ang II-challenged cells.
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spelling pubmed-83391432021-08-10 Deficiency of peroxisome proliferator-activated receptor α attenuates apoptosis and promotes migration of vascular smooth muscle cells Duan, Yan Qi, Dan Liu, Ye Song, Yanting Wang, Xia Jiao, Shiyu Li, Huihua Gonzalez, Frank J. Qi, Yongfen Xu, Qingbo Du, Jie Qu, Aijuan Biochem Biophys Rep Research Article Peroxisome proliferator-activated receptor (PPAR) α is widely expressed in the vasculature and has pleiotropic and lipid-lowering independent effects, but its role in the growth and function of vascular smooth muscle cells (VSMCs) during vascular pathophysiology is still unclear. Herein, VSMC-specific PPARα-deficient mice (Ppara(ΔSMC)) were generated by Cre-LoxP site-specific recombinase technology and VSMCs were isolated from mice aorta. PPARα deficiency attenuated VSMC apoptosis induced by angiotensin (Ang) II and hydrogen peroxide, and increased the migration of Ang II-challenged cells. Elsevier 2021-07-28 /pmc/articles/PMC8339143/ /pubmed/34381883 http://dx.doi.org/10.1016/j.bbrep.2021.101091 Text en © 2021 The Authors. Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Duan, Yan
Qi, Dan
Liu, Ye
Song, Yanting
Wang, Xia
Jiao, Shiyu
Li, Huihua
Gonzalez, Frank J.
Qi, Yongfen
Xu, Qingbo
Du, Jie
Qu, Aijuan
Deficiency of peroxisome proliferator-activated receptor α attenuates apoptosis and promotes migration of vascular smooth muscle cells
title Deficiency of peroxisome proliferator-activated receptor α attenuates apoptosis and promotes migration of vascular smooth muscle cells
title_full Deficiency of peroxisome proliferator-activated receptor α attenuates apoptosis and promotes migration of vascular smooth muscle cells
title_fullStr Deficiency of peroxisome proliferator-activated receptor α attenuates apoptosis and promotes migration of vascular smooth muscle cells
title_full_unstemmed Deficiency of peroxisome proliferator-activated receptor α attenuates apoptosis and promotes migration of vascular smooth muscle cells
title_short Deficiency of peroxisome proliferator-activated receptor α attenuates apoptosis and promotes migration of vascular smooth muscle cells
title_sort deficiency of peroxisome proliferator-activated receptor α attenuates apoptosis and promotes migration of vascular smooth muscle cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339143/
https://www.ncbi.nlm.nih.gov/pubmed/34381883
http://dx.doi.org/10.1016/j.bbrep.2021.101091
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