Cargando…
Three optimized assays for the evaluation of compounds that can rescue p53 mutants
Identifying drugs targeting p53 remains a major focus of precision oncology, with over twenty compounds that can rescue p53 mutants reported. Here, we suggest three easily accessible assays to determine the thermostability, protein folding, and transcriptional activity of p53 mutants—the go-to crite...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339244/ https://www.ncbi.nlm.nih.gov/pubmed/34382015 http://dx.doi.org/10.1016/j.xpro.2021.100688 |