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Roles of MicroRNAs in Glucose and Lipid Metabolism in the Heart
MicroRNAs (miRNAs) are small non-coding RNAs that participate in heart development and pathological processes mainly by silencing gene expression. Overwhelming evidence has suggested that miRNAs were involved in various cardiovascular pathological processes, including arrhythmias, ischemia-reperfusi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339264/ https://www.ncbi.nlm.nih.gov/pubmed/34368265 http://dx.doi.org/10.3389/fcvm.2021.716213 |
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author | Du, Hengzhi Zhao, Yanru Li, Huaping Wang, Dao Wen Chen, Chen |
author_facet | Du, Hengzhi Zhao, Yanru Li, Huaping Wang, Dao Wen Chen, Chen |
author_sort | Du, Hengzhi |
collection | PubMed |
description | MicroRNAs (miRNAs) are small non-coding RNAs that participate in heart development and pathological processes mainly by silencing gene expression. Overwhelming evidence has suggested that miRNAs were involved in various cardiovascular pathological processes, including arrhythmias, ischemia-reperfusion injuries, dysregulation of angiogenesis, mitochondrial abnormalities, fibrosis, and maladaptive remodeling. Various miRNAs could regulate myocardial contractility, vascular proliferation, and mitochondrial function. Meanwhile, it was reported that miRNAs could manipulate nutrition metabolism, especially glucose and lipid metabolism, by regulating insulin signaling pathways, energy substrate transport/metabolism. Recently, increasing studies suggested that the abnormal glucose and lipid metabolism were closely associated with a broad spectrum of cardiovascular diseases (CVDs). Therefore, maintaining glucose and lipid metabolism homeostasis in the heart might be beneficial to CVD patients. In this review, we summarized the present knowledge of the functions of miRNAs in regulating cardiac glucose and lipid metabolism, as well as highlighted the miRNA-based therapies targeting cardiac glucose and lipid metabolism. |
format | Online Article Text |
id | pubmed-8339264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83392642021-08-06 Roles of MicroRNAs in Glucose and Lipid Metabolism in the Heart Du, Hengzhi Zhao, Yanru Li, Huaping Wang, Dao Wen Chen, Chen Front Cardiovasc Med Cardiovascular Medicine MicroRNAs (miRNAs) are small non-coding RNAs that participate in heart development and pathological processes mainly by silencing gene expression. Overwhelming evidence has suggested that miRNAs were involved in various cardiovascular pathological processes, including arrhythmias, ischemia-reperfusion injuries, dysregulation of angiogenesis, mitochondrial abnormalities, fibrosis, and maladaptive remodeling. Various miRNAs could regulate myocardial contractility, vascular proliferation, and mitochondrial function. Meanwhile, it was reported that miRNAs could manipulate nutrition metabolism, especially glucose and lipid metabolism, by regulating insulin signaling pathways, energy substrate transport/metabolism. Recently, increasing studies suggested that the abnormal glucose and lipid metabolism were closely associated with a broad spectrum of cardiovascular diseases (CVDs). Therefore, maintaining glucose and lipid metabolism homeostasis in the heart might be beneficial to CVD patients. In this review, we summarized the present knowledge of the functions of miRNAs in regulating cardiac glucose and lipid metabolism, as well as highlighted the miRNA-based therapies targeting cardiac glucose and lipid metabolism. Frontiers Media S.A. 2021-07-22 /pmc/articles/PMC8339264/ /pubmed/34368265 http://dx.doi.org/10.3389/fcvm.2021.716213 Text en Copyright © 2021 Du, Zhao, Li, Wang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Du, Hengzhi Zhao, Yanru Li, Huaping Wang, Dao Wen Chen, Chen Roles of MicroRNAs in Glucose and Lipid Metabolism in the Heart |
title | Roles of MicroRNAs in Glucose and Lipid Metabolism in the Heart |
title_full | Roles of MicroRNAs in Glucose and Lipid Metabolism in the Heart |
title_fullStr | Roles of MicroRNAs in Glucose and Lipid Metabolism in the Heart |
title_full_unstemmed | Roles of MicroRNAs in Glucose and Lipid Metabolism in the Heart |
title_short | Roles of MicroRNAs in Glucose and Lipid Metabolism in the Heart |
title_sort | roles of micrornas in glucose and lipid metabolism in the heart |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339264/ https://www.ncbi.nlm.nih.gov/pubmed/34368265 http://dx.doi.org/10.3389/fcvm.2021.716213 |
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