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A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications

This article presents a versatile neurostimulation platform featuring a fully implantable multi-channel neural stimulator for chronic experimental studies with freely moving large animal models involving peripheral nerves. The implant is hermetically sealed in a ceramic enclosure and encapsulated in...

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Autores principales: Jiang, Dai, Liu, Fangqi, Lancashire, Henry T., Perkins, Timothy A., Schormans, Matthew, Vanhoestenberghe, Anne, Donaldson, Nicholas De N., Demosthenous, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339274/
https://www.ncbi.nlm.nih.gov/pubmed/34366773
http://dx.doi.org/10.3389/fnins.2021.681021
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author Jiang, Dai
Liu, Fangqi
Lancashire, Henry T.
Perkins, Timothy A.
Schormans, Matthew
Vanhoestenberghe, Anne
Donaldson, Nicholas De N.
Demosthenous, Andreas
author_facet Jiang, Dai
Liu, Fangqi
Lancashire, Henry T.
Perkins, Timothy A.
Schormans, Matthew
Vanhoestenberghe, Anne
Donaldson, Nicholas De N.
Demosthenous, Andreas
author_sort Jiang, Dai
collection PubMed
description This article presents a versatile neurostimulation platform featuring a fully implantable multi-channel neural stimulator for chronic experimental studies with freely moving large animal models involving peripheral nerves. The implant is hermetically sealed in a ceramic enclosure and encapsulated in medical grade silicone rubber, and then underwent active tests at accelerated aging conditions at 100°C for 15 consecutive days. The stimulator microelectronics are implemented in a 0.6-μm CMOS technology, with a crosstalk reduction scheme to minimize cross-channel interference, and high-speed power and data telemetry for battery-less operation. A wearable transmitter equipped with a Bluetooth Low Energy radio link, and a custom graphical user interface provide real-time, remotely controlled stimulation. Three parallel stimulators provide independent stimulation on three channels, where each stimulator supports six stimulating sites and two return sites through multiplexing, hence the implant can facilitate stimulation at up to 36 different electrode pairs. The design of the electronics, method of hermetic packaging and electrical performance as well as in vitro testing with electrodes in saline are presented.
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spelling pubmed-83392742021-08-06 A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications Jiang, Dai Liu, Fangqi Lancashire, Henry T. Perkins, Timothy A. Schormans, Matthew Vanhoestenberghe, Anne Donaldson, Nicholas De N. Demosthenous, Andreas Front Neurosci Neuroscience This article presents a versatile neurostimulation platform featuring a fully implantable multi-channel neural stimulator for chronic experimental studies with freely moving large animal models involving peripheral nerves. The implant is hermetically sealed in a ceramic enclosure and encapsulated in medical grade silicone rubber, and then underwent active tests at accelerated aging conditions at 100°C for 15 consecutive days. The stimulator microelectronics are implemented in a 0.6-μm CMOS technology, with a crosstalk reduction scheme to minimize cross-channel interference, and high-speed power and data telemetry for battery-less operation. A wearable transmitter equipped with a Bluetooth Low Energy radio link, and a custom graphical user interface provide real-time, remotely controlled stimulation. Three parallel stimulators provide independent stimulation on three channels, where each stimulator supports six stimulating sites and two return sites through multiplexing, hence the implant can facilitate stimulation at up to 36 different electrode pairs. The design of the electronics, method of hermetic packaging and electrical performance as well as in vitro testing with electrodes in saline are presented. Frontiers Media S.A. 2021-07-22 /pmc/articles/PMC8339274/ /pubmed/34366773 http://dx.doi.org/10.3389/fnins.2021.681021 Text en Copyright © 2021 Jiang, Liu, Lancashire, Perkins, Schormans, Vanhoestenberghe, Donaldson and Demosthenous. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Jiang, Dai
Liu, Fangqi
Lancashire, Henry T.
Perkins, Timothy A.
Schormans, Matthew
Vanhoestenberghe, Anne
Donaldson, Nicholas De N.
Demosthenous, Andreas
A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications
title A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications
title_full A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications
title_fullStr A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications
title_full_unstemmed A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications
title_short A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications
title_sort versatile hermetically sealed microelectronic implant for peripheral nerve stimulation applications
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339274/
https://www.ncbi.nlm.nih.gov/pubmed/34366773
http://dx.doi.org/10.3389/fnins.2021.681021
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