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Case Report: CBD Cigarettes for Harm Reduction and Adjunctive Therapy in a Patient With Schizophrenia and Substance Use Disorder

The treatment of patients with schizophrenia and substance use disorder poses a challenge for clinicians. Continued use of cannabis and cocaine can exacerbate psychotic symptoms and worsen the course of disease. To date, no pharmacotherapy is available for patients with cannabis use disorder (CUD)....

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Autores principales: Meyer, Maximilian, Walter, Marc, Borgwardt, Stefan, Scheidegger, Alexandra, Lang, Elisabeth, Köck, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339295/
https://www.ncbi.nlm.nih.gov/pubmed/34366942
http://dx.doi.org/10.3389/fpsyt.2021.712110
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author Meyer, Maximilian
Walter, Marc
Borgwardt, Stefan
Scheidegger, Alexandra
Lang, Elisabeth
Köck, Patrick
author_facet Meyer, Maximilian
Walter, Marc
Borgwardt, Stefan
Scheidegger, Alexandra
Lang, Elisabeth
Köck, Patrick
author_sort Meyer, Maximilian
collection PubMed
description The treatment of patients with schizophrenia and substance use disorder poses a challenge for clinicians. Continued use of cannabis and cocaine can exacerbate psychotic symptoms and worsen the course of disease. To date, no pharmacotherapy is available for patients with cannabis use disorder (CUD). Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are the main active constituents in Cannabis sativa, with the latter being linked to an increased risk of psychosis. We describe a clinical case of a male patient diagnosed with schizophrenia, combined personality disorder, CUD and cocaine use disorder. Over the course of 8 years, he was hospitalized 30 times due to psychotic relapses and continued substance use. Consequently, CBD cigarettes with a low THC content (<1%) were used as adjunctive therapy. Additionally, we established off-label treatment with methylphenidate to support abstinence. The patient reported to feel significantly less need to consume illegal cannabis with a high THC content. He stopped to use cocaine, for the time being, and has not been hospitalized since. This case report demonstrates the potential of smoked CBD as a substitute for severe and chronic CUD.
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spelling pubmed-83392952021-08-06 Case Report: CBD Cigarettes for Harm Reduction and Adjunctive Therapy in a Patient With Schizophrenia and Substance Use Disorder Meyer, Maximilian Walter, Marc Borgwardt, Stefan Scheidegger, Alexandra Lang, Elisabeth Köck, Patrick Front Psychiatry Psychiatry The treatment of patients with schizophrenia and substance use disorder poses a challenge for clinicians. Continued use of cannabis and cocaine can exacerbate psychotic symptoms and worsen the course of disease. To date, no pharmacotherapy is available for patients with cannabis use disorder (CUD). Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are the main active constituents in Cannabis sativa, with the latter being linked to an increased risk of psychosis. We describe a clinical case of a male patient diagnosed with schizophrenia, combined personality disorder, CUD and cocaine use disorder. Over the course of 8 years, he was hospitalized 30 times due to psychotic relapses and continued substance use. Consequently, CBD cigarettes with a low THC content (<1%) were used as adjunctive therapy. Additionally, we established off-label treatment with methylphenidate to support abstinence. The patient reported to feel significantly less need to consume illegal cannabis with a high THC content. He stopped to use cocaine, for the time being, and has not been hospitalized since. This case report demonstrates the potential of smoked CBD as a substitute for severe and chronic CUD. Frontiers Media S.A. 2021-07-22 /pmc/articles/PMC8339295/ /pubmed/34366942 http://dx.doi.org/10.3389/fpsyt.2021.712110 Text en Copyright © 2021 Meyer, Walter, Borgwardt, Scheidegger, Lang and Köck. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Meyer, Maximilian
Walter, Marc
Borgwardt, Stefan
Scheidegger, Alexandra
Lang, Elisabeth
Köck, Patrick
Case Report: CBD Cigarettes for Harm Reduction and Adjunctive Therapy in a Patient With Schizophrenia and Substance Use Disorder
title Case Report: CBD Cigarettes for Harm Reduction and Adjunctive Therapy in a Patient With Schizophrenia and Substance Use Disorder
title_full Case Report: CBD Cigarettes for Harm Reduction and Adjunctive Therapy in a Patient With Schizophrenia and Substance Use Disorder
title_fullStr Case Report: CBD Cigarettes for Harm Reduction and Adjunctive Therapy in a Patient With Schizophrenia and Substance Use Disorder
title_full_unstemmed Case Report: CBD Cigarettes for Harm Reduction and Adjunctive Therapy in a Patient With Schizophrenia and Substance Use Disorder
title_short Case Report: CBD Cigarettes for Harm Reduction and Adjunctive Therapy in a Patient With Schizophrenia and Substance Use Disorder
title_sort case report: cbd cigarettes for harm reduction and adjunctive therapy in a patient with schizophrenia and substance use disorder
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339295/
https://www.ncbi.nlm.nih.gov/pubmed/34366942
http://dx.doi.org/10.3389/fpsyt.2021.712110
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