A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging

Transition-metal chalcogenide compounds with facile preparation and multifunctional elements act as ideal photothermal agents for cancer theranostics. This work synthesizes Cu(7.2)S(4)/5MoS(2) composite nanoflowers and investigates the crystal growth mechanism to optimize the synthesis strategy and...

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Detalles Bibliográficos
Autores principales: Wu, Mingzhou, He, Shuqing, Hu, Xin, Chen, Jingqin, Ha, Enna, Ai, Fujin, Ji, Tao, Hu, Junqing, Ruan, Shuangchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339317/
https://www.ncbi.nlm.nih.gov/pubmed/34368079
http://dx.doi.org/10.3389/fchem.2021.695511
Descripción
Sumario:Transition-metal chalcogenide compounds with facile preparation and multifunctional elements act as ideal photothermal agents for cancer theranostics. This work synthesizes Cu(7.2)S(4)/5MoS(2) composite nanoflowers and investigates the crystal growth mechanism to optimize the synthesis strategy and obtain excellent photothermal therapy agents. Cu(7.2)S(4)/5MoS(2) exhibits a high photothermal conversion efficiency of 58.7% and acts as a theranostic nanoplatform and demonstrated an effective photothermal–chemodynamic–photodynamic synergetic therapeutic effect in both in vitro and in vivo tests. Moreover, Cu(7.2)S(4)/5MoS(2) shows strong photoacoustic signal amplitudes and computed tomographic contrast enhancement in vivo. These results suggest a potential application of Cu(7.2)S(4)/5MoS(2) composite nanoflowers as photo/H(2)O(2)-responsive therapeutic agents against tumors.

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