A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging

Transition-metal chalcogenide compounds with facile preparation and multifunctional elements act as ideal photothermal agents for cancer theranostics. This work synthesizes Cu(7.2)S(4)/5MoS(2) composite nanoflowers and investigates the crystal growth mechanism to optimize the synthesis strategy and...

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Autores principales: Wu, Mingzhou, He, Shuqing, Hu, Xin, Chen, Jingqin, Ha, Enna, Ai, Fujin, Ji, Tao, Hu, Junqing, Ruan, Shuangchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339317/
https://www.ncbi.nlm.nih.gov/pubmed/34368079
http://dx.doi.org/10.3389/fchem.2021.695511
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author Wu, Mingzhou
He, Shuqing
Hu, Xin
Chen, Jingqin
Ha, Enna
Ai, Fujin
Ji, Tao
Hu, Junqing
Ruan, Shuangchen
author_facet Wu, Mingzhou
He, Shuqing
Hu, Xin
Chen, Jingqin
Ha, Enna
Ai, Fujin
Ji, Tao
Hu, Junqing
Ruan, Shuangchen
author_sort Wu, Mingzhou
collection PubMed
description Transition-metal chalcogenide compounds with facile preparation and multifunctional elements act as ideal photothermal agents for cancer theranostics. This work synthesizes Cu(7.2)S(4)/5MoS(2) composite nanoflowers and investigates the crystal growth mechanism to optimize the synthesis strategy and obtain excellent photothermal therapy agents. Cu(7.2)S(4)/5MoS(2) exhibits a high photothermal conversion efficiency of 58.7% and acts as a theranostic nanoplatform and demonstrated an effective photothermal–chemodynamic–photodynamic synergetic therapeutic effect in both in vitro and in vivo tests. Moreover, Cu(7.2)S(4)/5MoS(2) shows strong photoacoustic signal amplitudes and computed tomographic contrast enhancement in vivo. These results suggest a potential application of Cu(7.2)S(4)/5MoS(2) composite nanoflowers as photo/H(2)O(2)-responsive therapeutic agents against tumors.
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spelling pubmed-83393172021-08-06 A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging Wu, Mingzhou He, Shuqing Hu, Xin Chen, Jingqin Ha, Enna Ai, Fujin Ji, Tao Hu, Junqing Ruan, Shuangchen Front Chem Chemistry Transition-metal chalcogenide compounds with facile preparation and multifunctional elements act as ideal photothermal agents for cancer theranostics. This work synthesizes Cu(7.2)S(4)/5MoS(2) composite nanoflowers and investigates the crystal growth mechanism to optimize the synthesis strategy and obtain excellent photothermal therapy agents. Cu(7.2)S(4)/5MoS(2) exhibits a high photothermal conversion efficiency of 58.7% and acts as a theranostic nanoplatform and demonstrated an effective photothermal–chemodynamic–photodynamic synergetic therapeutic effect in both in vitro and in vivo tests. Moreover, Cu(7.2)S(4)/5MoS(2) shows strong photoacoustic signal amplitudes and computed tomographic contrast enhancement in vivo. These results suggest a potential application of Cu(7.2)S(4)/5MoS(2) composite nanoflowers as photo/H(2)O(2)-responsive therapeutic agents against tumors. Frontiers Media S.A. 2021-07-22 /pmc/articles/PMC8339317/ /pubmed/34368079 http://dx.doi.org/10.3389/fchem.2021.695511 Text en Copyright © 2021 Wu, He, Hu, Chen, Ha, Ai, Ji, Hu and Ruan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Wu, Mingzhou
He, Shuqing
Hu, Xin
Chen, Jingqin
Ha, Enna
Ai, Fujin
Ji, Tao
Hu, Junqing
Ruan, Shuangchen
A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging
title A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging
title_full A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging
title_fullStr A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging
title_full_unstemmed A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging
title_short A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging
title_sort near-infrared light triggered composite nanoplatform for synergetic therapy and multimodal tumor imaging
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339317/
https://www.ncbi.nlm.nih.gov/pubmed/34368079
http://dx.doi.org/10.3389/fchem.2021.695511
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