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Ultrasonographic Estimation of Total Brain Volume: 3D Reliability and 2D Estimation. Enabling Routine Estimation During NICU Admission in the Preterm Infant

Objectives: The aim of this study is to explore if manually segmented total brain volume (TBV) from 3D ultrasonography (US) is comparable to TBV estimated by magnetic resonance imaging (MRI). We then wanted to test 2D based TBV estimation obtained through three linear axes which would enable monitor...

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Autores principales: Benavente-Fernández, Isabel, Ruiz-González, Estefanía, Lubian-Gutiérrez, Manuel, Lubián-Fernández, Simón Pedro, Cabrales Fontela, Yunior, Roca-Cornejo, Cristina, Olmo-Duran, Pedro, Lubián-López, Simón Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339409/
https://www.ncbi.nlm.nih.gov/pubmed/34368031
http://dx.doi.org/10.3389/fped.2021.708396
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author Benavente-Fernández, Isabel
Ruiz-González, Estefanía
Lubian-Gutiérrez, Manuel
Lubián-Fernández, Simón Pedro
Cabrales Fontela, Yunior
Roca-Cornejo, Cristina
Olmo-Duran, Pedro
Lubián-López, Simón Pedro
author_facet Benavente-Fernández, Isabel
Ruiz-González, Estefanía
Lubian-Gutiérrez, Manuel
Lubián-Fernández, Simón Pedro
Cabrales Fontela, Yunior
Roca-Cornejo, Cristina
Olmo-Duran, Pedro
Lubián-López, Simón Pedro
author_sort Benavente-Fernández, Isabel
collection PubMed
description Objectives: The aim of this study is to explore if manually segmented total brain volume (TBV) from 3D ultrasonography (US) is comparable to TBV estimated by magnetic resonance imaging (MRI). We then wanted to test 2D based TBV estimation obtained through three linear axes which would enable monitoring brain growth in the preterm infant during admission. Methods: We included very low birth weight preterm infants admitted to our neonatal intensive care unit (NICU) with normal neuroimaging findings. We measured biparietal diameter, anteroposterior axis, vertical axis from US and MRI and TBV from both MRI and 3D US. We calculated intra- and interobserver agreement within and between techniques using the intraclass correlation coefficient and Bland-Altman methodology. We then developed a multilevel prediction model of TBV based on linear measurements from both US and MRI, compared them and explored how they changed with increasing age. The multilevel prediction model for TBV from linear measures was tested for internal and external validity and we developed a reference table for ease of prediction of TBV. Results: We used measurements obtained from 426 US and 93 MRI scans from 118 patients. We found good intra- and interobserver agreement for all the measurements. US measurements were reliable when compared to MRI, including TBV which achieved excellent agreement with that of MRI [ICC of 0.98 (95% CI 0.96–0.99)]. TBV estimated through 2D measurements of biparietal diameter, anteroposterior axis, and vertical axis was comparable among both techniques. We estimated the population 95% confidence interval for the mean values of biparietal diameter, anteroposterior axis, vertical axis, and total brain volume by post-menstrual age. A TBV prediction table based on the three axes is proposed to enable easy implementation of TBV estimation in routine 2D US during admission in the NICU. Conclusions: US measurements of biparietal diameter, vertical axis, and anteroposterior axis are reliable. TBV segmented through 3D US is comparable to MRI estimated TBV. 2D US accurate estimation of TBV is possible through biparietal diameter, vertical, and anteroposterior axes.
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spelling pubmed-83394092021-08-06 Ultrasonographic Estimation of Total Brain Volume: 3D Reliability and 2D Estimation. Enabling Routine Estimation During NICU Admission in the Preterm Infant Benavente-Fernández, Isabel Ruiz-González, Estefanía Lubian-Gutiérrez, Manuel Lubián-Fernández, Simón Pedro Cabrales Fontela, Yunior Roca-Cornejo, Cristina Olmo-Duran, Pedro Lubián-López, Simón Pedro Front Pediatr Pediatrics Objectives: The aim of this study is to explore if manually segmented total brain volume (TBV) from 3D ultrasonography (US) is comparable to TBV estimated by magnetic resonance imaging (MRI). We then wanted to test 2D based TBV estimation obtained through three linear axes which would enable monitoring brain growth in the preterm infant during admission. Methods: We included very low birth weight preterm infants admitted to our neonatal intensive care unit (NICU) with normal neuroimaging findings. We measured biparietal diameter, anteroposterior axis, vertical axis from US and MRI and TBV from both MRI and 3D US. We calculated intra- and interobserver agreement within and between techniques using the intraclass correlation coefficient and Bland-Altman methodology. We then developed a multilevel prediction model of TBV based on linear measurements from both US and MRI, compared them and explored how they changed with increasing age. The multilevel prediction model for TBV from linear measures was tested for internal and external validity and we developed a reference table for ease of prediction of TBV. Results: We used measurements obtained from 426 US and 93 MRI scans from 118 patients. We found good intra- and interobserver agreement for all the measurements. US measurements were reliable when compared to MRI, including TBV which achieved excellent agreement with that of MRI [ICC of 0.98 (95% CI 0.96–0.99)]. TBV estimated through 2D measurements of biparietal diameter, anteroposterior axis, and vertical axis was comparable among both techniques. We estimated the population 95% confidence interval for the mean values of biparietal diameter, anteroposterior axis, vertical axis, and total brain volume by post-menstrual age. A TBV prediction table based on the three axes is proposed to enable easy implementation of TBV estimation in routine 2D US during admission in the NICU. Conclusions: US measurements of biparietal diameter, vertical axis, and anteroposterior axis are reliable. TBV segmented through 3D US is comparable to MRI estimated TBV. 2D US accurate estimation of TBV is possible through biparietal diameter, vertical, and anteroposterior axes. Frontiers Media S.A. 2021-07-22 /pmc/articles/PMC8339409/ /pubmed/34368031 http://dx.doi.org/10.3389/fped.2021.708396 Text en Copyright © 2021 Benavente-Fernández, Ruiz-González, Lubian-Gutiérrez, Lubián-Fernández, Cabrales Fontela, Roca-Cornejo, Olmo-Duran and Lubián-López. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Benavente-Fernández, Isabel
Ruiz-González, Estefanía
Lubian-Gutiérrez, Manuel
Lubián-Fernández, Simón Pedro
Cabrales Fontela, Yunior
Roca-Cornejo, Cristina
Olmo-Duran, Pedro
Lubián-López, Simón Pedro
Ultrasonographic Estimation of Total Brain Volume: 3D Reliability and 2D Estimation. Enabling Routine Estimation During NICU Admission in the Preterm Infant
title Ultrasonographic Estimation of Total Brain Volume: 3D Reliability and 2D Estimation. Enabling Routine Estimation During NICU Admission in the Preterm Infant
title_full Ultrasonographic Estimation of Total Brain Volume: 3D Reliability and 2D Estimation. Enabling Routine Estimation During NICU Admission in the Preterm Infant
title_fullStr Ultrasonographic Estimation of Total Brain Volume: 3D Reliability and 2D Estimation. Enabling Routine Estimation During NICU Admission in the Preterm Infant
title_full_unstemmed Ultrasonographic Estimation of Total Brain Volume: 3D Reliability and 2D Estimation. Enabling Routine Estimation During NICU Admission in the Preterm Infant
title_short Ultrasonographic Estimation of Total Brain Volume: 3D Reliability and 2D Estimation. Enabling Routine Estimation During NICU Admission in the Preterm Infant
title_sort ultrasonographic estimation of total brain volume: 3d reliability and 2d estimation. enabling routine estimation during nicu admission in the preterm infant
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339409/
https://www.ncbi.nlm.nih.gov/pubmed/34368031
http://dx.doi.org/10.3389/fped.2021.708396
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