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A very simple model to account for the rapid rise of the alpha variant of SARS-CoV-2 in several countries and the world

Since its first detection in the UK in September 2020, a highly contagious version of the coronavirus, the alpha or British variant a.k.a. B.1.1.7 SARS-CoV-2 virus lineage, rapidly spread across several countries and became the dominant strain in the outbreak. Here it is shown that a very simple evo...

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Autor principal: Fort, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339456/
https://www.ncbi.nlm.nih.gov/pubmed/34363849
http://dx.doi.org/10.1016/j.virusres.2021.198531
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author Fort, Hugo
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description Since its first detection in the UK in September 2020, a highly contagious version of the coronavirus, the alpha or British variant a.k.a. B.1.1.7 SARS-CoV-2 virus lineage, rapidly spread across several countries and became the dominant strain in the outbreak. Here it is shown that a very simple evolutionary model can fit the observed change in frequency of B.1.1.7 for several countries, regions of countries and the whole world with a single parameter, its relative fitness f, which is almost universal f ≈ 1.5. This is consistent with a 50% higher transmissibility than the local wild type and with the fact that the period in which this variant takes over has been in all the studied cases around 22 weeks.
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spelling pubmed-83394562021-08-06 A very simple model to account for the rapid rise of the alpha variant of SARS-CoV-2 in several countries and the world Fort, Hugo Virus Res Short Communication Since its first detection in the UK in September 2020, a highly contagious version of the coronavirus, the alpha or British variant a.k.a. B.1.1.7 SARS-CoV-2 virus lineage, rapidly spread across several countries and became the dominant strain in the outbreak. Here it is shown that a very simple evolutionary model can fit the observed change in frequency of B.1.1.7 for several countries, regions of countries and the whole world with a single parameter, its relative fitness f, which is almost universal f ≈ 1.5. This is consistent with a 50% higher transmissibility than the local wild type and with the fact that the period in which this variant takes over has been in all the studied cases around 22 weeks. Elsevier B.V. 2021-10-15 2021-08-05 /pmc/articles/PMC8339456/ /pubmed/34363849 http://dx.doi.org/10.1016/j.virusres.2021.198531 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Fort, Hugo
A very simple model to account for the rapid rise of the alpha variant of SARS-CoV-2 in several countries and the world
title A very simple model to account for the rapid rise of the alpha variant of SARS-CoV-2 in several countries and the world
title_full A very simple model to account for the rapid rise of the alpha variant of SARS-CoV-2 in several countries and the world
title_fullStr A very simple model to account for the rapid rise of the alpha variant of SARS-CoV-2 in several countries and the world
title_full_unstemmed A very simple model to account for the rapid rise of the alpha variant of SARS-CoV-2 in several countries and the world
title_short A very simple model to account for the rapid rise of the alpha variant of SARS-CoV-2 in several countries and the world
title_sort very simple model to account for the rapid rise of the alpha variant of sars-cov-2 in several countries and the world
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339456/
https://www.ncbi.nlm.nih.gov/pubmed/34363849
http://dx.doi.org/10.1016/j.virusres.2021.198531
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