A Case of Acquired von Willebrand Syndrome Complicated by Acute Myelomonocytic Leukemia

We here report a 21-year-old male who presented with acute myelomonocytic leukemia (AMML) associated with acquired von Willebrand syndrome (AVWS). To our knowledge, this is the first case of AVWS caused by AMML. In our case, following remission-induction chemotherapy combined with idarubicin and cyt...

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Autores principales: Fukatsu, Masahiko, Ohkawara, Hiroshi, Takahashi, Hiroshi, Mori, Hirotaka, Yaginuma, Mai, Endo, Mamiko, Shichishima-Nakamura, Akiko, Sano, Takahiro, Harada-Shirado, Kayo, Kimura, Satoshi, Ogawa, Kazuei, Hashimoto, Yuko, Ikezoe, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339464/
https://www.ncbi.nlm.nih.gov/pubmed/34413747
http://dx.doi.org/10.1159/000517439
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author Fukatsu, Masahiko
Ohkawara, Hiroshi
Takahashi, Hiroshi
Mori, Hirotaka
Yaginuma, Mai
Endo, Mamiko
Shichishima-Nakamura, Akiko
Sano, Takahiro
Harada-Shirado, Kayo
Kimura, Satoshi
Ogawa, Kazuei
Hashimoto, Yuko
Ikezoe, Takayuki
author_facet Fukatsu, Masahiko
Ohkawara, Hiroshi
Takahashi, Hiroshi
Mori, Hirotaka
Yaginuma, Mai
Endo, Mamiko
Shichishima-Nakamura, Akiko
Sano, Takahiro
Harada-Shirado, Kayo
Kimura, Satoshi
Ogawa, Kazuei
Hashimoto, Yuko
Ikezoe, Takayuki
author_sort Fukatsu, Masahiko
collection PubMed
description We here report a 21-year-old male who presented with acute myelomonocytic leukemia (AMML) associated with acquired von Willebrand syndrome (AVWS). To our knowledge, this is the first case of AVWS caused by AMML. In our case, following remission-induction chemotherapy combined with idarubicin and cytarabine, the patient showed remarkable improvement of bleeding symptoms due to AVWS. Moreover, after an allogeneic stem cell transplantation from a sibling donor, both AMML and AVWS maintain complete remission.
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spelling pubmed-83394642021-08-18 A Case of Acquired von Willebrand Syndrome Complicated by Acute Myelomonocytic Leukemia Fukatsu, Masahiko Ohkawara, Hiroshi Takahashi, Hiroshi Mori, Hirotaka Yaginuma, Mai Endo, Mamiko Shichishima-Nakamura, Akiko Sano, Takahiro Harada-Shirado, Kayo Kimura, Satoshi Ogawa, Kazuei Hashimoto, Yuko Ikezoe, Takayuki Case Rep Oncol Case Report We here report a 21-year-old male who presented with acute myelomonocytic leukemia (AMML) associated with acquired von Willebrand syndrome (AVWS). To our knowledge, this is the first case of AVWS caused by AMML. In our case, following remission-induction chemotherapy combined with idarubicin and cytarabine, the patient showed remarkable improvement of bleeding symptoms due to AVWS. Moreover, after an allogeneic stem cell transplantation from a sibling donor, both AMML and AVWS maintain complete remission. S. Karger AG 2021-07-20 /pmc/articles/PMC8339464/ /pubmed/34413747 http://dx.doi.org/10.1159/000517439 Text en Copyright © 2021 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Fukatsu, Masahiko
Ohkawara, Hiroshi
Takahashi, Hiroshi
Mori, Hirotaka
Yaginuma, Mai
Endo, Mamiko
Shichishima-Nakamura, Akiko
Sano, Takahiro
Harada-Shirado, Kayo
Kimura, Satoshi
Ogawa, Kazuei
Hashimoto, Yuko
Ikezoe, Takayuki
A Case of Acquired von Willebrand Syndrome Complicated by Acute Myelomonocytic Leukemia
title A Case of Acquired von Willebrand Syndrome Complicated by Acute Myelomonocytic Leukemia
title_full A Case of Acquired von Willebrand Syndrome Complicated by Acute Myelomonocytic Leukemia
title_fullStr A Case of Acquired von Willebrand Syndrome Complicated by Acute Myelomonocytic Leukemia
title_full_unstemmed A Case of Acquired von Willebrand Syndrome Complicated by Acute Myelomonocytic Leukemia
title_short A Case of Acquired von Willebrand Syndrome Complicated by Acute Myelomonocytic Leukemia
title_sort case of acquired von willebrand syndrome complicated by acute myelomonocytic leukemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339464/
https://www.ncbi.nlm.nih.gov/pubmed/34413747
http://dx.doi.org/10.1159/000517439
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