Sub-cutaneous Pfizer/BioNTech COVID-19 vaccine administration results in seroconversion among young adults

Route of vaccine administration plays a role in extent and quality of immunogenicity. 790 military personnel accidentally received the first of two doses of Pfizer/BioNTech mRNA anti Covid-19 vaccine using a needle intended for subcutaneous administration. A serological blood test (on day 21, prior...

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Detalles Bibliográficos
Autores principales: Friedensohn, Limor, Zur, Meital, Timofeyev, Maxim, Burshtein, Saar, Ben Michael, Yossi, Fink, Noam, Glassberg, Elon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339541/
https://www.ncbi.nlm.nih.gov/pubmed/34531083
http://dx.doi.org/10.1016/j.vaccine.2021.07.096
Descripción
Sumario:Route of vaccine administration plays a role in extent and quality of immunogenicity. 790 military personnel accidentally received the first of two doses of Pfizer/BioNTech mRNA anti Covid-19 vaccine using a needle intended for subcutaneous administration. A serological blood test (on day 21, prior to the second intramuscular dose) was performed, analyzing whether immunological response was elicited. 98.2% demonstrated seroconversion. IgG titers were negatively correlated with age and did not correlate with BMI. Our results could help reassure providers confronted with a similar mistake and may even imply a possibly new and effective administration route.

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