Sub-cutaneous Pfizer/BioNTech COVID-19 vaccine administration results in seroconversion among young adults

Route of vaccine administration plays a role in extent and quality of immunogenicity. 790 military personnel accidentally received the first of two doses of Pfizer/BioNTech mRNA anti Covid-19 vaccine using a needle intended for subcutaneous administration. A serological blood test (on day 21, prior...

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Autores principales: Friedensohn, Limor, Zur, Meital, Timofeyev, Maxim, Burshtein, Saar, Ben Michael, Yossi, Fink, Noam, Glassberg, Elon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339541/
https://www.ncbi.nlm.nih.gov/pubmed/34531083
http://dx.doi.org/10.1016/j.vaccine.2021.07.096
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author Friedensohn, Limor
Zur, Meital
Timofeyev, Maxim
Burshtein, Saar
Ben Michael, Yossi
Fink, Noam
Glassberg, Elon
author_facet Friedensohn, Limor
Zur, Meital
Timofeyev, Maxim
Burshtein, Saar
Ben Michael, Yossi
Fink, Noam
Glassberg, Elon
author_sort Friedensohn, Limor
collection PubMed
description Route of vaccine administration plays a role in extent and quality of immunogenicity. 790 military personnel accidentally received the first of two doses of Pfizer/BioNTech mRNA anti Covid-19 vaccine using a needle intended for subcutaneous administration. A serological blood test (on day 21, prior to the second intramuscular dose) was performed, analyzing whether immunological response was elicited. 98.2% demonstrated seroconversion. IgG titers were negatively correlated with age and did not correlate with BMI. Our results could help reassure providers confronted with a similar mistake and may even imply a possibly new and effective administration route.
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spelling pubmed-83395412021-08-06 Sub-cutaneous Pfizer/BioNTech COVID-19 vaccine administration results in seroconversion among young adults Friedensohn, Limor Zur, Meital Timofeyev, Maxim Burshtein, Saar Ben Michael, Yossi Fink, Noam Glassberg, Elon Vaccine Short Communication Route of vaccine administration plays a role in extent and quality of immunogenicity. 790 military personnel accidentally received the first of two doses of Pfizer/BioNTech mRNA anti Covid-19 vaccine using a needle intended for subcutaneous administration. A serological blood test (on day 21, prior to the second intramuscular dose) was performed, analyzing whether immunological response was elicited. 98.2% demonstrated seroconversion. IgG titers were negatively correlated with age and did not correlate with BMI. Our results could help reassure providers confronted with a similar mistake and may even imply a possibly new and effective administration route. Elsevier Ltd. 2021-10-08 2021-08-05 /pmc/articles/PMC8339541/ /pubmed/34531083 http://dx.doi.org/10.1016/j.vaccine.2021.07.096 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Friedensohn, Limor
Zur, Meital
Timofeyev, Maxim
Burshtein, Saar
Ben Michael, Yossi
Fink, Noam
Glassberg, Elon
Sub-cutaneous Pfizer/BioNTech COVID-19 vaccine administration results in seroconversion among young adults
title Sub-cutaneous Pfizer/BioNTech COVID-19 vaccine administration results in seroconversion among young adults
title_full Sub-cutaneous Pfizer/BioNTech COVID-19 vaccine administration results in seroconversion among young adults
title_fullStr Sub-cutaneous Pfizer/BioNTech COVID-19 vaccine administration results in seroconversion among young adults
title_full_unstemmed Sub-cutaneous Pfizer/BioNTech COVID-19 vaccine administration results in seroconversion among young adults
title_short Sub-cutaneous Pfizer/BioNTech COVID-19 vaccine administration results in seroconversion among young adults
title_sort sub-cutaneous pfizer/biontech covid-19 vaccine administration results in seroconversion among young adults
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339541/
https://www.ncbi.nlm.nih.gov/pubmed/34531083
http://dx.doi.org/10.1016/j.vaccine.2021.07.096
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