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Zebrafish as a Model for Germ Cell Regeneration

Germ cell acts as a link between transfer of genetic information and process of species evolution. Defects or malformations of germ cells can lead to infertility or tumors. Germ cell regeneration is one of the effective ways to treat the infertility. Therefore, it is of great scientific and clinical...

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Autores principales: Cao, Zigang, Yang, Qifen, Luo, Lingfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339553/
https://www.ncbi.nlm.nih.gov/pubmed/34368134
http://dx.doi.org/10.3389/fcell.2021.685001
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author Cao, Zigang
Yang, Qifen
Luo, Lingfei
author_facet Cao, Zigang
Yang, Qifen
Luo, Lingfei
author_sort Cao, Zigang
collection PubMed
description Germ cell acts as a link between transfer of genetic information and process of species evolution. Defects or malformations of germ cells can lead to infertility or tumors. Germ cell regeneration is one of the effective ways to treat the infertility. Therefore, it is of great scientific and clinical interests to dissect the cellular and molecular mechanisms underlying germ cell regeneration. Progress have already been achieved in germ cell regeneration using model organisms for decades. However, key open issues regarding the underpinning mechanisms still remain poorly understood. Zebrafish is well known for its powerful regenerative capacity to regenerate various tissues and organs. Recently, advances in genomics, genetics, microscopy, and single cell technologies have made zebrafish an attractive model to study germ cell development and regeneration. Here we review recent technologies for the study of germ cell regeneration in zebrafish, highlight the potential of germline stem cells (GSCs) in the contribution to reproductive system regeneration, and discuss the nanos. Wnt signaling and germ cell-specific factors involved in the regulation of germ cell regeneration.
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spelling pubmed-83395532021-08-06 Zebrafish as a Model for Germ Cell Regeneration Cao, Zigang Yang, Qifen Luo, Lingfei Front Cell Dev Biol Cell and Developmental Biology Germ cell acts as a link between transfer of genetic information and process of species evolution. Defects or malformations of germ cells can lead to infertility or tumors. Germ cell regeneration is one of the effective ways to treat the infertility. Therefore, it is of great scientific and clinical interests to dissect the cellular and molecular mechanisms underlying germ cell regeneration. Progress have already been achieved in germ cell regeneration using model organisms for decades. However, key open issues regarding the underpinning mechanisms still remain poorly understood. Zebrafish is well known for its powerful regenerative capacity to regenerate various tissues and organs. Recently, advances in genomics, genetics, microscopy, and single cell technologies have made zebrafish an attractive model to study germ cell development and regeneration. Here we review recent technologies for the study of germ cell regeneration in zebrafish, highlight the potential of germline stem cells (GSCs) in the contribution to reproductive system regeneration, and discuss the nanos. Wnt signaling and germ cell-specific factors involved in the regulation of germ cell regeneration. Frontiers Media S.A. 2021-07-22 /pmc/articles/PMC8339553/ /pubmed/34368134 http://dx.doi.org/10.3389/fcell.2021.685001 Text en Copyright © 2021 Cao, Yang and Luo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Cao, Zigang
Yang, Qifen
Luo, Lingfei
Zebrafish as a Model for Germ Cell Regeneration
title Zebrafish as a Model for Germ Cell Regeneration
title_full Zebrafish as a Model for Germ Cell Regeneration
title_fullStr Zebrafish as a Model for Germ Cell Regeneration
title_full_unstemmed Zebrafish as a Model for Germ Cell Regeneration
title_short Zebrafish as a Model for Germ Cell Regeneration
title_sort zebrafish as a model for germ cell regeneration
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339553/
https://www.ncbi.nlm.nih.gov/pubmed/34368134
http://dx.doi.org/10.3389/fcell.2021.685001
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