Janus Kinase Inhibition Ameliorates Ischemic Stroke Injury and Neuroinflammation Through Reducing NLRP3 Inflammasome Activation via JAK2/STAT3 Pathway Inhibition

BACKGROUND: Inflammatory responses play a multiphase role in the pathogenesis of cerebral ischemic stroke (IS). Ruxolitinib (Rux), a selective oral JAK 1/2 inhibitor, reduces inflammatory responses via the JAK2/STAT3 pathway. Based on its anti-inflammatory and immunosuppressive effects, we hypothesi...

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Detalles Bibliográficos
Autores principales: Zhu, Hua, Jian, Zhihong, Zhong, Yi, Ye, Yingze, Zhang, Yonggang, Hu, Xinyao, Pu, Bei, Gu, Lijuan, Xiong, Xiaoxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339584/
https://www.ncbi.nlm.nih.gov/pubmed/34367186
http://dx.doi.org/10.3389/fimmu.2021.714943

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