Inclusion of cGAMP within virus‐like particle vaccines enhances their immunogenicity

Cyclic GMP‐AMP (cGAMP) is an immunostimulatory molecule produced by cGAS that activates STING. cGAMP is an adjuvant when administered alongside antigens. cGAMP is also incorporated into enveloped virus particles during budding. Here, we investigate whether inclusion of cGAMP within viral vaccine vec...

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Detalles Bibliográficos
Autores principales: Chauveau, Lise, Bridgeman, Anne, Tan, Tiong K, Beveridge, Ryan, Frost, Joe N, Rijal, Pramila, Pedroza‐Pacheco, Isabela, Partridge, Thomas, Gilbert‐Jaramillo, Javier, Knight, Michael L, Liu, Xu, Russell, Rebecca A, Borrow, Persephone, Drakesmith, Hal, Townsend, Alain R, Rehwinkel, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339669/
https://www.ncbi.nlm.nih.gov/pubmed/34142428
http://dx.doi.org/10.15252/embr.202152447

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