Polygenic score modifies risk for Alzheimer's disease in APOE ε4 homozygotes at phenotypic extremes

INTRODUCTION: Diversity in cognition among apolipoprotein E (APOE) ε4 homozygotes can range from early‐onset Alzheimer's disease (AD) to a lifetime with no symptoms. METHODS: We evaluated a phenotypic extreme polygenic risk score (PRS) for AD between cognitively healthy APOE ε4 homozygotes aged...

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Detalles Bibliográficos
Autores principales: Huq, Aamira J., Fulton‐Howard, Brian, Riaz, Moeen, Laws, Simon, Sebra, Robert, Ryan, Joanne, Renton, Alan E., Goate, Alison M., Masters, Colin L., Storey, Elsdon, Shah, Raj C., Murray, Anne, McNeil, John, Winship, Ingrid, James, Paul A., Lacaze, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339682/
https://www.ncbi.nlm.nih.gov/pubmed/34386572
http://dx.doi.org/10.1002/dad2.12226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339682/
https://www.ncbi.nlm.nih.gov/pubmed/34386572
http://dx.doi.org/10.1002/dad2.12226

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