Synthetic Integrin-Targeting Dextran-Fc Hybrids Efficiently Inhibit Tumor Proliferation In Vitro

Herein, we present the design, synthesis, and biological evaluation of novel integrin-targeting molecular hybrids combining RGD peptides and a potent cytotoxin presented on dextran polysaccharides. Based on an aglycosylated Fc as a centerpiece, endosomal-cleavable cytotoxic agent monomethyl auristat...

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Detalles Bibliográficos
Autores principales: Schneider, Hendrik, Englert, Simon, Macarrón Palacios, Arturo, Lerma Romero, Jorge Alberto, Ali, Ataurehman, Avrutina, Olga, Kolmar, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339797/
https://www.ncbi.nlm.nih.gov/pubmed/34368077
http://dx.doi.org/10.3389/fchem.2021.693097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339797/
https://www.ncbi.nlm.nih.gov/pubmed/34368077
http://dx.doi.org/10.3389/fchem.2021.693097

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