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Long Non-coding RNA Regulation of Mesenchymal Stem Cell Homeostasis and Differentiation: Advances, Challenges, and Perspectives

Given the self-renewal, multi-differentiation, immunoregulatory, and tissue maintenance properties, mesenchymal stem cells (MSCs) are promising candidates for stem cell-based therapies. Breakthroughs have been made in uncovering MSCs as key contributors to homeostasis and the regenerative repair of...

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Autores principales: Yang, Yanlei, Liu, Suying, He, Chengmei, Chen, Zhilei, Lyu, Taibiao, Zeng, Liuting, Wang, Li, Zhang, Fengchun, Chen, Hua, Zhao, Robert Chunhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339964/
https://www.ncbi.nlm.nih.gov/pubmed/34368161
http://dx.doi.org/10.3389/fcell.2021.711005
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author Yang, Yanlei
Liu, Suying
He, Chengmei
Chen, Zhilei
Lyu, Taibiao
Zeng, Liuting
Wang, Li
Zhang, Fengchun
Chen, Hua
Zhao, Robert Chunhua
author_facet Yang, Yanlei
Liu, Suying
He, Chengmei
Chen, Zhilei
Lyu, Taibiao
Zeng, Liuting
Wang, Li
Zhang, Fengchun
Chen, Hua
Zhao, Robert Chunhua
author_sort Yang, Yanlei
collection PubMed
description Given the self-renewal, multi-differentiation, immunoregulatory, and tissue maintenance properties, mesenchymal stem cells (MSCs) are promising candidates for stem cell-based therapies. Breakthroughs have been made in uncovering MSCs as key contributors to homeostasis and the regenerative repair of tissues and organs derived from three germ layers. MSC differentiation into specialized cell types is sophisticatedly regulated, and accumulating evidence suggests long non-coding RNAs (lncRNAs) as the master regulators of various biological processes including the maintenance of homeostasis and multi-differentiation functions through epigenetic, transcriptional, and post-translational mechanisms. LncRNAs are ubiquitous and generally referred to as non-coding transcripts longer than 200 bp. Most lncRNAs are evolutionary conserved and species-specific; however, the weak conservation of their sequences across species does not affect their diverse biological functions. Although numerous lncRNAs have been annotated and studied, they are nevertheless only the tip of the iceberg; the rest remain to be discovered. In this review, we characterize MSC functions in homeostasis and highlight recent advances on the functions and mechanisms of lncRNAs in regulating MSC homeostasis and differentiation. We also discuss the current challenges and perspectives for understanding the roles of lncRNAs in MSC functions in homeostasis, which could help develop promising targets for MSC-based therapies.
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spelling pubmed-83399642021-08-06 Long Non-coding RNA Regulation of Mesenchymal Stem Cell Homeostasis and Differentiation: Advances, Challenges, and Perspectives Yang, Yanlei Liu, Suying He, Chengmei Chen, Zhilei Lyu, Taibiao Zeng, Liuting Wang, Li Zhang, Fengchun Chen, Hua Zhao, Robert Chunhua Front Cell Dev Biol Cell and Developmental Biology Given the self-renewal, multi-differentiation, immunoregulatory, and tissue maintenance properties, mesenchymal stem cells (MSCs) are promising candidates for stem cell-based therapies. Breakthroughs have been made in uncovering MSCs as key contributors to homeostasis and the regenerative repair of tissues and organs derived from three germ layers. MSC differentiation into specialized cell types is sophisticatedly regulated, and accumulating evidence suggests long non-coding RNAs (lncRNAs) as the master regulators of various biological processes including the maintenance of homeostasis and multi-differentiation functions through epigenetic, transcriptional, and post-translational mechanisms. LncRNAs are ubiquitous and generally referred to as non-coding transcripts longer than 200 bp. Most lncRNAs are evolutionary conserved and species-specific; however, the weak conservation of their sequences across species does not affect their diverse biological functions. Although numerous lncRNAs have been annotated and studied, they are nevertheless only the tip of the iceberg; the rest remain to be discovered. In this review, we characterize MSC functions in homeostasis and highlight recent advances on the functions and mechanisms of lncRNAs in regulating MSC homeostasis and differentiation. We also discuss the current challenges and perspectives for understanding the roles of lncRNAs in MSC functions in homeostasis, which could help develop promising targets for MSC-based therapies. Frontiers Media S.A. 2021-07-22 /pmc/articles/PMC8339964/ /pubmed/34368161 http://dx.doi.org/10.3389/fcell.2021.711005 Text en Copyright © 2021 Yang, Liu, He, Chen, Lyu, Zeng, Wang, Zhang, Chen and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Yang, Yanlei
Liu, Suying
He, Chengmei
Chen, Zhilei
Lyu, Taibiao
Zeng, Liuting
Wang, Li
Zhang, Fengchun
Chen, Hua
Zhao, Robert Chunhua
Long Non-coding RNA Regulation of Mesenchymal Stem Cell Homeostasis and Differentiation: Advances, Challenges, and Perspectives
title Long Non-coding RNA Regulation of Mesenchymal Stem Cell Homeostasis and Differentiation: Advances, Challenges, and Perspectives
title_full Long Non-coding RNA Regulation of Mesenchymal Stem Cell Homeostasis and Differentiation: Advances, Challenges, and Perspectives
title_fullStr Long Non-coding RNA Regulation of Mesenchymal Stem Cell Homeostasis and Differentiation: Advances, Challenges, and Perspectives
title_full_unstemmed Long Non-coding RNA Regulation of Mesenchymal Stem Cell Homeostasis and Differentiation: Advances, Challenges, and Perspectives
title_short Long Non-coding RNA Regulation of Mesenchymal Stem Cell Homeostasis and Differentiation: Advances, Challenges, and Perspectives
title_sort long non-coding rna regulation of mesenchymal stem cell homeostasis and differentiation: advances, challenges, and perspectives
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339964/
https://www.ncbi.nlm.nih.gov/pubmed/34368161
http://dx.doi.org/10.3389/fcell.2021.711005
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