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Enteromorpha polysaccharide-zinc replacing prophylactic antibiotics contributes to improving gut health of weaned piglets
This research aimed to study whether Enteromorpha polysaccharide-zinc (EP-Zn) can act as an alternative to antibiotics in weaned piglet feeds. Two hundred and twenty-four weaned piglets from 14 pens were randomly assigned into 1 of 2 groups according to their body weight and litter size (7 pens/grou...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340054/ https://www.ncbi.nlm.nih.gov/pubmed/34401542 http://dx.doi.org/10.1016/j.aninu.2021.01.008 |
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author | Xie, Chunyan Zhang, Yumei Niu, Kaimin Liang, Xiaoxiao Wang, Haihua Shan, Junwei Wu, Xin |
author_facet | Xie, Chunyan Zhang, Yumei Niu, Kaimin Liang, Xiaoxiao Wang, Haihua Shan, Junwei Wu, Xin |
author_sort | Xie, Chunyan |
collection | PubMed |
description | This research aimed to study whether Enteromorpha polysaccharide-zinc (EP-Zn) can act as an alternative to antibiotics in weaned piglet feeds. Two hundred and twenty-four weaned piglets from 14 pens were randomly assigned into 1 of 2 groups according to their body weight and litter size (7 pens/group). The piglets in the antibiotics group were fed with olaquindox at 400 mg/kg and enduracidin at 800 mg/kg basal diet, and piglets in the EP-Zn group were fed with EP-Zn at 800 mg/kg basal diet. One piglet per pen was selected to collect samples after 14 d of feeding. Results showed that EP-Zn supplementation significantly increased the plasma anti-oxidants level compared with the antibiotics group. However, a nonsignificant difference was observed in growth performance between treatment groups. Additionally, the intestinal tight junction (TJ) protein expression and the histopathologic evaluation data showed that EP-Zn contributed to improving intestinal development. Further, piglets in the EP-Zn group had a lower level of intestinal inflammation-related cytokines including IL-6 (P < 0.001), IL-8 (P < 0.05), IL-12 (P < 0.05) and tumor necrosis factor-α (TNF-α) (P < 0.001), and showed an inhibition of the phosphorylation nuclear transcription factor-kappa B (p–NF–κB) (P < 0.05) and total NF-κB (P < 0.001) level in the jejunal mucosa. Taken together, it is supposed that EP-Zn, to some extent, would be a potent alternative to prophylactic antibiotics in improving the health status of weaned piglets. |
format | Online Article Text |
id | pubmed-8340054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-83400542021-08-15 Enteromorpha polysaccharide-zinc replacing prophylactic antibiotics contributes to improving gut health of weaned piglets Xie, Chunyan Zhang, Yumei Niu, Kaimin Liang, Xiaoxiao Wang, Haihua Shan, Junwei Wu, Xin Anim Nutr Original Research Article This research aimed to study whether Enteromorpha polysaccharide-zinc (EP-Zn) can act as an alternative to antibiotics in weaned piglet feeds. Two hundred and twenty-four weaned piglets from 14 pens were randomly assigned into 1 of 2 groups according to their body weight and litter size (7 pens/group). The piglets in the antibiotics group were fed with olaquindox at 400 mg/kg and enduracidin at 800 mg/kg basal diet, and piglets in the EP-Zn group were fed with EP-Zn at 800 mg/kg basal diet. One piglet per pen was selected to collect samples after 14 d of feeding. Results showed that EP-Zn supplementation significantly increased the plasma anti-oxidants level compared with the antibiotics group. However, a nonsignificant difference was observed in growth performance between treatment groups. Additionally, the intestinal tight junction (TJ) protein expression and the histopathologic evaluation data showed that EP-Zn contributed to improving intestinal development. Further, piglets in the EP-Zn group had a lower level of intestinal inflammation-related cytokines including IL-6 (P < 0.001), IL-8 (P < 0.05), IL-12 (P < 0.05) and tumor necrosis factor-α (TNF-α) (P < 0.001), and showed an inhibition of the phosphorylation nuclear transcription factor-kappa B (p–NF–κB) (P < 0.05) and total NF-κB (P < 0.001) level in the jejunal mucosa. Taken together, it is supposed that EP-Zn, to some extent, would be a potent alternative to prophylactic antibiotics in improving the health status of weaned piglets. KeAi Publishing 2021-09 2021-07-02 /pmc/articles/PMC8340054/ /pubmed/34401542 http://dx.doi.org/10.1016/j.aninu.2021.01.008 Text en © 2021 Chinese Association of Animal Science and Veterinary Medicine. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Article Xie, Chunyan Zhang, Yumei Niu, Kaimin Liang, Xiaoxiao Wang, Haihua Shan, Junwei Wu, Xin Enteromorpha polysaccharide-zinc replacing prophylactic antibiotics contributes to improving gut health of weaned piglets |
title | Enteromorpha polysaccharide-zinc replacing prophylactic antibiotics contributes to improving gut health of weaned piglets |
title_full | Enteromorpha polysaccharide-zinc replacing prophylactic antibiotics contributes to improving gut health of weaned piglets |
title_fullStr | Enteromorpha polysaccharide-zinc replacing prophylactic antibiotics contributes to improving gut health of weaned piglets |
title_full_unstemmed | Enteromorpha polysaccharide-zinc replacing prophylactic antibiotics contributes to improving gut health of weaned piglets |
title_short | Enteromorpha polysaccharide-zinc replacing prophylactic antibiotics contributes to improving gut health of weaned piglets |
title_sort | enteromorpha polysaccharide-zinc replacing prophylactic antibiotics contributes to improving gut health of weaned piglets |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340054/ https://www.ncbi.nlm.nih.gov/pubmed/34401542 http://dx.doi.org/10.1016/j.aninu.2021.01.008 |
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