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Low level of plasminogen increases risk for mortality in COVID-19 patients
The pathophysiology of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and especially of its complications is still not fully understood. In fact, a very high number of patients with COVID-19 die because of thromboembolic causes. A role of...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340078/ https://www.ncbi.nlm.nih.gov/pubmed/34354045 http://dx.doi.org/10.1038/s41419-021-04070-3 |
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author | Della-Morte, David Pacifici, Francesca Ricordi, Camillo Massoud, Renato Rovella, Valentina Proietti, Stefania Iozzo, Mariannina Lauro, Davide Bernardini, Sergio Bonassi, Stefano Di Daniele, Nicola |
author_facet | Della-Morte, David Pacifici, Francesca Ricordi, Camillo Massoud, Renato Rovella, Valentina Proietti, Stefania Iozzo, Mariannina Lauro, Davide Bernardini, Sergio Bonassi, Stefano Di Daniele, Nicola |
author_sort | Della-Morte, David |
collection | PubMed |
description | The pathophysiology of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and especially of its complications is still not fully understood. In fact, a very high number of patients with COVID-19 die because of thromboembolic causes. A role of plasminogen, as precursor of fibrinolysis, has been hypothesized. In this study, we aimed to investigate the association between plasminogen levels and COVID-19-related outcomes in a population of 55 infected Caucasian patients (mean age: 69.8 ± 14.3, 41.8% female). Low levels of plasminogen were significantly associated with inflammatory markers (CRP, PCT, and IL-6), markers of coagulation (D-dimer, INR, and APTT), and markers of organ dysfunctions (high fasting blood glucose and decrease in the glomerular filtration rate). A multidimensional analysis model, including the correlation of the expression of coagulation with inflammatory parameters, indicated that plasminogen tended to cluster together with IL-6, hence suggesting a common pathway of activation during disease’s complication. Moreover, low levels of plasminogen strongly correlated with mortality in COVID-19 patients even after multiple adjustments for presence of confounding. These data suggest that plasminogen may play a pivotal role in controlling the complex mechanisms beyond the COVID-19 complications, and may be useful both as biomarker for prognosis and for therapeutic target against this extremely aggressive infection. |
format | Online Article Text |
id | pubmed-8340078 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-83400782021-08-06 Low level of plasminogen increases risk for mortality in COVID-19 patients Della-Morte, David Pacifici, Francesca Ricordi, Camillo Massoud, Renato Rovella, Valentina Proietti, Stefania Iozzo, Mariannina Lauro, Davide Bernardini, Sergio Bonassi, Stefano Di Daniele, Nicola Cell Death Dis Article The pathophysiology of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and especially of its complications is still not fully understood. In fact, a very high number of patients with COVID-19 die because of thromboembolic causes. A role of plasminogen, as precursor of fibrinolysis, has been hypothesized. In this study, we aimed to investigate the association between plasminogen levels and COVID-19-related outcomes in a population of 55 infected Caucasian patients (mean age: 69.8 ± 14.3, 41.8% female). Low levels of plasminogen were significantly associated with inflammatory markers (CRP, PCT, and IL-6), markers of coagulation (D-dimer, INR, and APTT), and markers of organ dysfunctions (high fasting blood glucose and decrease in the glomerular filtration rate). A multidimensional analysis model, including the correlation of the expression of coagulation with inflammatory parameters, indicated that plasminogen tended to cluster together with IL-6, hence suggesting a common pathway of activation during disease’s complication. Moreover, low levels of plasminogen strongly correlated with mortality in COVID-19 patients even after multiple adjustments for presence of confounding. These data suggest that plasminogen may play a pivotal role in controlling the complex mechanisms beyond the COVID-19 complications, and may be useful both as biomarker for prognosis and for therapeutic target against this extremely aggressive infection. Nature Publishing Group UK 2021-08-05 /pmc/articles/PMC8340078/ /pubmed/34354045 http://dx.doi.org/10.1038/s41419-021-04070-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Della-Morte, David Pacifici, Francesca Ricordi, Camillo Massoud, Renato Rovella, Valentina Proietti, Stefania Iozzo, Mariannina Lauro, Davide Bernardini, Sergio Bonassi, Stefano Di Daniele, Nicola Low level of plasminogen increases risk for mortality in COVID-19 patients |
title | Low level of plasminogen increases risk for mortality in COVID-19 patients |
title_full | Low level of plasminogen increases risk for mortality in COVID-19 patients |
title_fullStr | Low level of plasminogen increases risk for mortality in COVID-19 patients |
title_full_unstemmed | Low level of plasminogen increases risk for mortality in COVID-19 patients |
title_short | Low level of plasminogen increases risk for mortality in COVID-19 patients |
title_sort | low level of plasminogen increases risk for mortality in covid-19 patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340078/ https://www.ncbi.nlm.nih.gov/pubmed/34354045 http://dx.doi.org/10.1038/s41419-021-04070-3 |
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