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Association of lipocalin-2 and low-density lipoprotein receptor-related protein-1 (LRP1) with biomarkers of environmental enteric dysfunction (EED) among under 2 children in Bangladesh: results from a community-based intervention study

BACKGROUND: Environmental enteric dysfunction (EED) is thought to occur from persistent intestinal inflammation. Studies also revealed the association of lipocalin-2 (LCN2) and low-density lipoprotein receptor-related protein-1 (LRP1) with intestinal inflammation. Therefore, we intended to explore t...

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Autores principales: Hasan, Md. Mehedi, Gazi, Md. Amran, Das, Subhasish, Fahim, Shah Mohammad, Hossaini, Farzana, Alam, Md. Ashraful, Mahfuz, Mustafa, Ahmed, Tahmeed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340289/
https://www.ncbi.nlm.nih.gov/pubmed/34423140
http://dx.doi.org/10.1136/bmjpo-2021-001138
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author Hasan, Md. Mehedi
Gazi, Md. Amran
Das, Subhasish
Fahim, Shah Mohammad
Hossaini, Farzana
Alam, Md. Ashraful
Mahfuz, Mustafa
Ahmed, Tahmeed
author_facet Hasan, Md. Mehedi
Gazi, Md. Amran
Das, Subhasish
Fahim, Shah Mohammad
Hossaini, Farzana
Alam, Md. Ashraful
Mahfuz, Mustafa
Ahmed, Tahmeed
author_sort Hasan, Md. Mehedi
collection PubMed
description BACKGROUND: Environmental enteric dysfunction (EED) is thought to occur from persistent intestinal inflammation. Studies also revealed the association of lipocalin-2 (LCN2) and low-density lipoprotein receptor-related protein-1 (LRP1) with intestinal inflammation. Therefore, we intended to explore the relationship of LCN2 and LRP1 with gut inflammation and biomarkers of EED in Bangladeshi malnourished children. METHODS: A total of 222 children (length-for-age z-score (LAZ) <-1) aged 12–18 months were enrolled in this study in a cross-sectional manner. Among the participants, 115 were stunted (LAZ <-2) and 107 were at risk of being stunted (LAZ −1 to −2) children. Plasma and faecal biomarkers were measured using ELISA. Spearman’s rank correlation was done to see the correlation among LCN2, LRP1 and biological biomarkers. RESULTS: LCN2 correlates positively with myeloperoxidase (r=0.19, p=0.005), neopterin (r=0.20, p=0.004), calprotectin (r=0.3, p=0.0001), Reg1B (r=0.20, p=0.003) and EED score (r=0.20, p=0.003). Whereas, LRP1 correlates negatively with myeloperoxidase (r = −0.18, p=0.006), neopterin (r = −0.30, p=0.0001), alpha-1-antitrypsin (r = −0.18, p=0.006), Reg1B (r=−0.2, p=0.003) and EED score (r = −0.29, p=0.0001). CONCLUSIONS: Our findings imply that LCN2 might be a promising biomarker to predict gut inflammation and EED. Whereas, increased level of LRP1 may contribute to alleviating intestinal inflammation.
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spelling pubmed-83402892021-08-20 Association of lipocalin-2 and low-density lipoprotein receptor-related protein-1 (LRP1) with biomarkers of environmental enteric dysfunction (EED) among under 2 children in Bangladesh: results from a community-based intervention study Hasan, Md. Mehedi Gazi, Md. Amran Das, Subhasish Fahim, Shah Mohammad Hossaini, Farzana Alam, Md. Ashraful Mahfuz, Mustafa Ahmed, Tahmeed BMJ Paediatr Open General Paediatrics BACKGROUND: Environmental enteric dysfunction (EED) is thought to occur from persistent intestinal inflammation. Studies also revealed the association of lipocalin-2 (LCN2) and low-density lipoprotein receptor-related protein-1 (LRP1) with intestinal inflammation. Therefore, we intended to explore the relationship of LCN2 and LRP1 with gut inflammation and biomarkers of EED in Bangladeshi malnourished children. METHODS: A total of 222 children (length-for-age z-score (LAZ) <-1) aged 12–18 months were enrolled in this study in a cross-sectional manner. Among the participants, 115 were stunted (LAZ <-2) and 107 were at risk of being stunted (LAZ −1 to −2) children. Plasma and faecal biomarkers were measured using ELISA. Spearman’s rank correlation was done to see the correlation among LCN2, LRP1 and biological biomarkers. RESULTS: LCN2 correlates positively with myeloperoxidase (r=0.19, p=0.005), neopterin (r=0.20, p=0.004), calprotectin (r=0.3, p=0.0001), Reg1B (r=0.20, p=0.003) and EED score (r=0.20, p=0.003). Whereas, LRP1 correlates negatively with myeloperoxidase (r = −0.18, p=0.006), neopterin (r = −0.30, p=0.0001), alpha-1-antitrypsin (r = −0.18, p=0.006), Reg1B (r=−0.2, p=0.003) and EED score (r = −0.29, p=0.0001). CONCLUSIONS: Our findings imply that LCN2 might be a promising biomarker to predict gut inflammation and EED. Whereas, increased level of LRP1 may contribute to alleviating intestinal inflammation. BMJ Publishing Group 2021-08-04 /pmc/articles/PMC8340289/ /pubmed/34423140 http://dx.doi.org/10.1136/bmjpo-2021-001138 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle General Paediatrics
Hasan, Md. Mehedi
Gazi, Md. Amran
Das, Subhasish
Fahim, Shah Mohammad
Hossaini, Farzana
Alam, Md. Ashraful
Mahfuz, Mustafa
Ahmed, Tahmeed
Association of lipocalin-2 and low-density lipoprotein receptor-related protein-1 (LRP1) with biomarkers of environmental enteric dysfunction (EED) among under 2 children in Bangladesh: results from a community-based intervention study
title Association of lipocalin-2 and low-density lipoprotein receptor-related protein-1 (LRP1) with biomarkers of environmental enteric dysfunction (EED) among under 2 children in Bangladesh: results from a community-based intervention study
title_full Association of lipocalin-2 and low-density lipoprotein receptor-related protein-1 (LRP1) with biomarkers of environmental enteric dysfunction (EED) among under 2 children in Bangladesh: results from a community-based intervention study
title_fullStr Association of lipocalin-2 and low-density lipoprotein receptor-related protein-1 (LRP1) with biomarkers of environmental enteric dysfunction (EED) among under 2 children in Bangladesh: results from a community-based intervention study
title_full_unstemmed Association of lipocalin-2 and low-density lipoprotein receptor-related protein-1 (LRP1) with biomarkers of environmental enteric dysfunction (EED) among under 2 children in Bangladesh: results from a community-based intervention study
title_short Association of lipocalin-2 and low-density lipoprotein receptor-related protein-1 (LRP1) with biomarkers of environmental enteric dysfunction (EED) among under 2 children in Bangladesh: results from a community-based intervention study
title_sort association of lipocalin-2 and low-density lipoprotein receptor-related protein-1 (lrp1) with biomarkers of environmental enteric dysfunction (eed) among under 2 children in bangladesh: results from a community-based intervention study
topic General Paediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340289/
https://www.ncbi.nlm.nih.gov/pubmed/34423140
http://dx.doi.org/10.1136/bmjpo-2021-001138
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