Genomic profiling of solid tumors harboring BRD4-NUT and response to immune checkpoint inhibitors

BACKGROUND: The translocation t(15:19) produces the oncogenic BRD4-NUT fusion which is pathognomonic for NUT carcinoma (NC), which is a rare, but extremely aggressive solid tumor. Comprehensive genomic profiling (CGP) by hybrid-capture based next generation sequencing of 186+ genes of a cohort of ad...

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Detalles Bibliográficos
Autores principales: Riess, Jonathan W., Rahman, Shaila, Kian, Waleed, Edgerly, Claire, Heilmann, Andreas M., Madison, Russell, Ramkissoon, Shakti H., Klaitman, Shai Shlomi, Chung, Jon H., Trabucco, Sally E., Jin, Dexter X., Alexander, Brian M., Klempner, Samuel J., Albacker, Lee A., Frampton, Garrett M., Roisman, Laila C., Miller, Vincent A., Ross, Jeffrey S., Schrock, Alexa B., Gregg, Jeffrey P., Peled, Nir, Sokol, Ethan S., Ali, Siraj M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340305/
https://www.ncbi.nlm.nih.gov/pubmed/34333275
http://dx.doi.org/10.1016/j.tranon.2021.101184

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