Synthesis and Catalytic Activities of 3-Decyl-β-proline for Michael Reactions in Water without an Organic Solvent

[Image: see text] 3-Decyl-β-proline, which has a highly lipophilic substituent, was synthesized, and its catalytic activities in Michael addition using water as the solvent were investigated. The decyl substituent promoted the reaction by hydrophobic interactions to afford the Michael adduct in a hi...

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Detalles Bibliográficos
Autores principales: Nagata, Kazuhiro, Nakagawa, Chihiro, Yokoyama, Wakana, Usui, Haruka, Mochizuki, Rikako, Kanemitsu, Takuya, Miyazaki, Michiko, Itoh, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340436/
https://www.ncbi.nlm.nih.gov/pubmed/34368551
http://dx.doi.org/10.1021/acsomega.1c02289
Descripción
Sumario:[Image: see text] 3-Decyl-β-proline, which has a highly lipophilic substituent, was synthesized, and its catalytic activities in Michael addition using water as the solvent were investigated. The decyl substituent promoted the reaction by hydrophobic interactions to afford the Michael adduct in a high yield and with high diastereoselectivity under low catalyst loading.

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