SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions

BACKGROUND: 3-phosphoinositide-dependent protein kinase-1 (PDK1) acts as a master kinase of protein kinase A, G, and C family (AGC) kinase to predominantly govern cell survival, proliferation, and metabolic homeostasis. Although the regulations to PDK1 downstream substrates such as protein kinase B...

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Detalles Bibliográficos
Autores principales: Jiang, Qiwei, Zheng, Nana, Bu, Lang, Zhang, Xiaomei, Zhang, Xiaoling, Wu, Yuanzhong, Su, Yaqing, Wang, Lei, Zhang, Xiaomin, Ren, Shancheng, Dai, Xiangpeng, Wu, Depei, Xie, Wei, Wei, Wenyi, Zhu, Yasheng, Guo, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340461/
https://www.ncbi.nlm.nih.gov/pubmed/34353330
http://dx.doi.org/10.1186/s12943-021-01397-5

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