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Longitudinal Changes of Tongue Thickness and Tongue Pressure in Neuromuscular Disorders
BACKGROUND: Swallowing dysfunction is related to major cause of adverse events and an indicator of shorter survival among patients with neuromuscular disorders (NMD). It is critical to assess the swallowing function during disease progression, however, there are limited tools that can easily evaluat...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340465/ https://www.ncbi.nlm.nih.gov/pubmed/34353291 http://dx.doi.org/10.1186/s12883-021-02225-5 |
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author | Umemoto, George Fujioka, Shinsuke Arahata, Hajime Sakae, Nobutaka Sasagasako, Naokazu Toda, Mine Furuya, Hirokazu Tsuboi, Yoshio |
author_facet | Umemoto, George Fujioka, Shinsuke Arahata, Hajime Sakae, Nobutaka Sasagasako, Naokazu Toda, Mine Furuya, Hirokazu Tsuboi, Yoshio |
author_sort | Umemoto, George |
collection | PubMed |
description | BACKGROUND: Swallowing dysfunction is related to major cause of adverse events and an indicator of shorter survival among patients with neuromuscular disorders (NMD). It is critical to assess the swallowing function during disease progression, however, there are limited tools that can easily evaluate swallowing function without using videofluoroscopic or videoendoscopic examination. Here, we evaluated the longitudinal changes in tongue thickness (TT) and maximum tongue pressure (MTP) among patients with amyotrophic lateral sclerosis (ALS), myotonic dystrophy type 1 (DM1), and Duchenne muscular dystrophy (DMD). METHODS: Between 2010 and 2020, TT and MTP were measured from 21 ALS, 30 DM1, and 14 DMD patients (mean ages of 66.9, 44.5, and 21.4 years, respectively) at intervals of more than half a year. TT was measured, by ultrasonography, as the distance from the mylohyoid muscle raphe to the tongue dorsum, and MTP was determined by measuring the maximum compression on a small balloon when pressing the tongue against the palate. Then we examined the relationship between these evaluations and patient background and swallowing function. RESULTS: Mean follow-up periods were 24.0 months in the ALS group, 47.2 months in the DM1group, and 61.1 months in the DMD group. The DMD group demonstrated larger first TT than the other groups, while the DM1 group had lower first MTP than the ALS group. The ALS group showed a greater average monthly reduction in mean TT than the DM1 group and greater monthly reductions in mean body weight (BW) and MTP than the other groups. Significant differences between the first and last BW, TT, and MTP measures were found only in the ALS group. CONCLUSIONS: This study suggests that ALS is associated with more rapid degeneration of tongue function over several years compared to DMD and DM1. |
format | Online Article Text |
id | pubmed-8340465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-83404652021-08-06 Longitudinal Changes of Tongue Thickness and Tongue Pressure in Neuromuscular Disorders Umemoto, George Fujioka, Shinsuke Arahata, Hajime Sakae, Nobutaka Sasagasako, Naokazu Toda, Mine Furuya, Hirokazu Tsuboi, Yoshio BMC Neurol Research Article BACKGROUND: Swallowing dysfunction is related to major cause of adverse events and an indicator of shorter survival among patients with neuromuscular disorders (NMD). It is critical to assess the swallowing function during disease progression, however, there are limited tools that can easily evaluate swallowing function without using videofluoroscopic or videoendoscopic examination. Here, we evaluated the longitudinal changes in tongue thickness (TT) and maximum tongue pressure (MTP) among patients with amyotrophic lateral sclerosis (ALS), myotonic dystrophy type 1 (DM1), and Duchenne muscular dystrophy (DMD). METHODS: Between 2010 and 2020, TT and MTP were measured from 21 ALS, 30 DM1, and 14 DMD patients (mean ages of 66.9, 44.5, and 21.4 years, respectively) at intervals of more than half a year. TT was measured, by ultrasonography, as the distance from the mylohyoid muscle raphe to the tongue dorsum, and MTP was determined by measuring the maximum compression on a small balloon when pressing the tongue against the palate. Then we examined the relationship between these evaluations and patient background and swallowing function. RESULTS: Mean follow-up periods were 24.0 months in the ALS group, 47.2 months in the DM1group, and 61.1 months in the DMD group. The DMD group demonstrated larger first TT than the other groups, while the DM1 group had lower first MTP than the ALS group. The ALS group showed a greater average monthly reduction in mean TT than the DM1 group and greater monthly reductions in mean body weight (BW) and MTP than the other groups. Significant differences between the first and last BW, TT, and MTP measures were found only in the ALS group. CONCLUSIONS: This study suggests that ALS is associated with more rapid degeneration of tongue function over several years compared to DMD and DM1. BioMed Central 2021-08-05 /pmc/articles/PMC8340465/ /pubmed/34353291 http://dx.doi.org/10.1186/s12883-021-02225-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Umemoto, George Fujioka, Shinsuke Arahata, Hajime Sakae, Nobutaka Sasagasako, Naokazu Toda, Mine Furuya, Hirokazu Tsuboi, Yoshio Longitudinal Changes of Tongue Thickness and Tongue Pressure in Neuromuscular Disorders |
title | Longitudinal Changes of Tongue Thickness and Tongue Pressure in Neuromuscular Disorders |
title_full | Longitudinal Changes of Tongue Thickness and Tongue Pressure in Neuromuscular Disorders |
title_fullStr | Longitudinal Changes of Tongue Thickness and Tongue Pressure in Neuromuscular Disorders |
title_full_unstemmed | Longitudinal Changes of Tongue Thickness and Tongue Pressure in Neuromuscular Disorders |
title_short | Longitudinal Changes of Tongue Thickness and Tongue Pressure in Neuromuscular Disorders |
title_sort | longitudinal changes of tongue thickness and tongue pressure in neuromuscular disorders |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340465/ https://www.ncbi.nlm.nih.gov/pubmed/34353291 http://dx.doi.org/10.1186/s12883-021-02225-5 |
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