Molecular docking analysis of stevioside with Akt and PPARγ

Stevioside is a diterpenoid glycoside consisting of an aglycone (steviol) and three glucose molecules. It is commonly used as an anti-hyperglycemic food because of its non-caloric property. Therefore, it is of interest to document the interactions of stevioside with AKT & PPAR-γ proteins using A...

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Autores principales: Deenadayalan, Abilasha, Vijayalakshmi, S, Janaki, CS, Jayaraman, Selvaraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340692/
https://www.ncbi.nlm.nih.gov/pubmed/34393447
http://dx.doi.org/10.6026/97320630017283
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author Deenadayalan, Abilasha
Vijayalakshmi, S
Janaki, CS
Jayaraman, Selvaraj
author_facet Deenadayalan, Abilasha
Vijayalakshmi, S
Janaki, CS
Jayaraman, Selvaraj
author_sort Deenadayalan, Abilasha
collection PubMed
description Stevioside is a diterpenoid glycoside consisting of an aglycone (steviol) and three glucose molecules. It is commonly used as an anti-hyperglycemic food because of its non-caloric property. Therefore, it is of interest to document the interactions of stevioside with AKT & PPAR-γ proteins using Autodock Vina PyRx docking techniques. Results of the docking studies indicate that stevioside had more than two hydrogen bond interactions with the AKT and PPAR γ protein for further consideration.
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spelling pubmed-83406922021-08-12 Molecular docking analysis of stevioside with Akt and PPARγ Deenadayalan, Abilasha Vijayalakshmi, S Janaki, CS Jayaraman, Selvaraj Bioinformation Research Article Stevioside is a diterpenoid glycoside consisting of an aglycone (steviol) and three glucose molecules. It is commonly used as an anti-hyperglycemic food because of its non-caloric property. Therefore, it is of interest to document the interactions of stevioside with AKT & PPAR-γ proteins using Autodock Vina PyRx docking techniques. Results of the docking studies indicate that stevioside had more than two hydrogen bond interactions with the AKT and PPAR γ protein for further consideration. Biomedical Informatics 2021-01-31 /pmc/articles/PMC8340692/ /pubmed/34393447 http://dx.doi.org/10.6026/97320630017283 Text en © 2021 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Deenadayalan, Abilasha
Vijayalakshmi, S
Janaki, CS
Jayaraman, Selvaraj
Molecular docking analysis of stevioside with Akt and PPARγ
title Molecular docking analysis of stevioside with Akt and PPARγ
title_full Molecular docking analysis of stevioside with Akt and PPARγ
title_fullStr Molecular docking analysis of stevioside with Akt and PPARγ
title_full_unstemmed Molecular docking analysis of stevioside with Akt and PPARγ
title_short Molecular docking analysis of stevioside with Akt and PPARγ
title_sort molecular docking analysis of stevioside with akt and pparγ
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340692/
https://www.ncbi.nlm.nih.gov/pubmed/34393447
http://dx.doi.org/10.6026/97320630017283
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