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Crystal structure, Hirshfeld surface analysis and inter­action energy calculation of 4-(furan-2-yl)-2-(6-methyl-2,4-dioxo­pyran-3-yl­idene)-2,3,4,5-tetra­hydro-1H-1,5-benzodiazepine

The title compound {systematic name: (S,E)-3-[4-(furan-2-yl)-2,3,4,5-tetra­hydro-1H-benzo[b][1,4]diazepin-2-yl­idene]-6-methyl-2H-pyran-2,4(3H)-dione}, C(19)H(16)N(2)O(4), is constructed from a benzodiazepine ring system linked to furan and pendant di­hydro­pyran rings, where the benzene and furan r...

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Detalles Bibliográficos
Autores principales: El Hafi, Mohamed, Lahmidi, Sanae, El Ghayati, Lhoussaine, Hökelek, Tuncer, Mague, Joel T., Amer, Bushra, Sebbar, Nada Kheira, Essassi, El Mokhtar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340973/
https://www.ncbi.nlm.nih.gov/pubmed/34422311
http://dx.doi.org/10.1107/S2056989021007441
Descripción
Sumario:The title compound {systematic name: (S,E)-3-[4-(furan-2-yl)-2,3,4,5-tetra­hydro-1H-benzo[b][1,4]diazepin-2-yl­idene]-6-methyl-2H-pyran-2,4(3H)-dione}, C(19)H(16)N(2)O(4), is constructed from a benzodiazepine ring system linked to furan and pendant di­hydro­pyran rings, where the benzene and furan rings are oriented at a dihedral angle of 48.7 (2)°. The pyran ring is modestly non-planar [largest deviation of 0.029 (4) Å from the least-squares plane] while the tetra­hydro­diazepine ring adopts a boat conformation. The rotational orientation of the pendant di­hydro­pyran ring is partially determined by an intra­molecular N—H(Diazp)⋯O(Dhydp) (Diazp = diazepine and Dhydp = di­hydro­pyran) hydrogen bond. In the crystal, layers of mol­ecules parallel to the bc plane are formed by N—H(Diazp)⋯O(Dhydp) hydrogen bonds and slipped π–π stacking inter­actions. The layers are connected by additional slipped π–π stacking inter­actions. A Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from H⋯H (46.8%), H⋯O/O⋯H (23.5%) and H⋯C/C⋯H (15.8%) inter­actions, indicating that van der Waals inter­actions are the dominant forces in the crystal packing. Computational chemistry indicates that in the crystal the N—H⋯O hydrogen-bond energy is 57.5 kJ mol(−1).