Withanolides from Physalis angulata L.

The compounds (17S,20R,22R,24R,25S)-5β,6β:20,24-diep­oxy-4β,25-dihy­droxy-1-oxowith-2-en-26,22-olide and (20R,22R)-5α,14α,20-Trihy­droxy-1-oxo-6α,7α-ep­oxy­witha-2-enolide were isolated from a chloro­form extract of the aerial parts of Physalis angulata L. (Solanaceae). Two products were isolated fr...

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Detalles Bibliográficos
Autores principales: Okmanov, R. Ya., Makhmudova, M. M., Bobaev, I. D., Tashkhodjaev, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2021
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340980/
https://www.ncbi.nlm.nih.gov/pubmed/34422305
http://dx.doi.org/10.1107/S205698902100709X
Descripción
Sumario:The compounds (17S,20R,22R,24R,25S)-5β,6β:20,24-diep­oxy-4β,25-dihy­droxy-1-oxowith-2-en-26,22-olide and (20R,22R)-5α,14α,20-Trihy­droxy-1-oxo-6α,7α-ep­oxy­witha-2-enolide were isolated from a chloro­form extract of the aerial parts of Physalis angulata L. (Solanaceae). Two products were isolated from the chromatographic separation extract. Compound I corresponds to physangulide B chloro­form monosolvate, C(28)H(38)O(7)·CHCl(3), while compound II is 14α-hy­droxy­ixocarpanolide, C(28)H(40)O(7). In the two mol­ecular structures, the conformation of the steroid part (rings A, B, C, D) does not differ. In both crystals, mol­ecules are linked by inter­molecular O—H⋯O hydrogen bonds along the c-axis direction and form a two-dimensional network parallel to the ac plane. The absolute configuration was determined from X-ray diffraction data.

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