Synthetic hyperacetylation of nucleosomal histones

We report combinations of a DMAP-based catalyst and phenyl acetate with optimal electron density as a new chemical system for high-yield, selective synthetic acetylation of histone lysine residues. The utility of this chemical system as a unique biologic tool is demonstrated by applying it to Xenopu...

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Detalles Bibliográficos
Autores principales: Kajino, Hidetoshi, Nagatani, Tomomi, Oi, Miku, Kujirai, Tomoya, Kurumizaka, Hitoshi, Nishiyama, Atsuya, Nakanishi, Makoto, Yamatsugu, Kenzo, Kawashima, Shigehiro A., Kanai, Motomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341002/
https://www.ncbi.nlm.nih.gov/pubmed/34458748
http://dx.doi.org/10.1039/d0cb00029a
Descripción
Sumario:We report combinations of a DMAP-based catalyst and phenyl acetate with optimal electron density as a new chemical system for high-yield, selective synthetic acetylation of histone lysine residues. The utility of this chemical system as a unique biologic tool is demonstrated by applying it to Xenopus laevis sperm chromatin.

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