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Mapping the energy landscape of protein–ligand binding via linear free energy relationships determined by protein NMR relaxation dispersion

Biochemical signaling is mediated by complexes between macromolecular receptors and their ligands, with the duration of the signal being directly related to the lifetime of the ligand–receptor complex. In the field of drug design, the recognition that drug efficacy in vivo depends on the lifetime of...

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Detalles Bibliográficos
Autores principales:	Stenström, Olof, Diehl, Carl, Modig, Kristofer, Nilsson, Ulf J., Akke, Mikael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341105/ https://www.ncbi.nlm.nih.gov/pubmed/34458786 http://dx.doi.org/10.1039/d0cb00229a

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