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Gastric antral vascular ectasia in hepatitis C virus related liver cirrhosis: Fetching for predictors
BACKGROUND AND AIM: Gastric antral vascular ectasia (GAVE) is observed in patients with liver cirrhosis and portal hypertension. The exact pathophysiologic mechanism that underlies this condition is unknown. In our study, we estimate the prevalence of GAVE in hepatitis C virus (HCV) cirrhosis and at...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Publishing Asia Pty Ltd
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341197/ https://www.ncbi.nlm.nih.gov/pubmed/34386601 http://dx.doi.org/10.1002/jgh3.12607 |
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author | Fouad, Magdy Khalaf Fath‐Elbab, Hanaa Mostafa, Alaa Mohamed Moness, Hend M Adel, Nashwa Mohamed Ahmed, Elham |
author_facet | Fouad, Magdy Khalaf Fath‐Elbab, Hanaa Mostafa, Alaa Mohamed Moness, Hend M Adel, Nashwa Mohamed Ahmed, Elham |
author_sort | Fouad, Magdy |
collection | PubMed |
description | BACKGROUND AND AIM: Gastric antral vascular ectasia (GAVE) is observed in patients with liver cirrhosis and portal hypertension. The exact pathophysiologic mechanism that underlies this condition is unknown. In our study, we estimate the prevalence of GAVE in hepatitis C virus (HCV) cirrhosis and attempted to determine if any of the hepatocellular manifestations, liver functions, serum gastrin, abdominal ultrasound and endoscopic picture have a relation to, or could predict, the occurrence of GAVE in cirrhotic patients. METHODS: This study includes 500 HCV‐related liver cirrhosis patients. According to endoscopic assessment, we detected 30 patients with GAVE (Group 2). From the 470 patients without GAVE, we randomly selected 120 patients (Group 1), to avoid statistical bias, for comparison with Group 2. Comparison included clinical manifestations, laboratory findings, serum gastrin, ultrasound findings, and endoscopic findings (esophageal and/or gastric varices and gastropathy). RESULTS: The percentage of GAVE in HCV‐related liver cirrhosis is 0.06%. We can predict GAVE by platelets, palmer erythema, diabetes mellitus (DM), marked ascites > with area under the curve of 0.67, 75.5, 0.62, and 0.40%, and accuracy of 82.5, 72, 70.7, and 79.3%, respectively. There was no correlation found between occurrence of GAVE and endoscopic findings. Also, there was no correlation found between occurrence of GAVE and serum gastrin levels, which reflect another pathophysiology, and we found no statistically significant correlation with GAVE. CONCLUSIONS: Palmer erythema, low platelets, DM, and ascites might help in the prediction of GAVE. GAVE is not linked to the presence, type or grade of varices, and gastropathy. |
format | Online Article Text |
id | pubmed-8341197 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wiley Publishing Asia Pty Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-83411972021-08-11 Gastric antral vascular ectasia in hepatitis C virus related liver cirrhosis: Fetching for predictors Fouad, Magdy Khalaf Fath‐Elbab, Hanaa Mostafa, Alaa Mohamed Moness, Hend M Adel, Nashwa Mohamed Ahmed, Elham JGH Open Original Articles BACKGROUND AND AIM: Gastric antral vascular ectasia (GAVE) is observed in patients with liver cirrhosis and portal hypertension. The exact pathophysiologic mechanism that underlies this condition is unknown. In our study, we estimate the prevalence of GAVE in hepatitis C virus (HCV) cirrhosis and attempted to determine if any of the hepatocellular manifestations, liver functions, serum gastrin, abdominal ultrasound and endoscopic picture have a relation to, or could predict, the occurrence of GAVE in cirrhotic patients. METHODS: This study includes 500 HCV‐related liver cirrhosis patients. According to endoscopic assessment, we detected 30 patients with GAVE (Group 2). From the 470 patients without GAVE, we randomly selected 120 patients (Group 1), to avoid statistical bias, for comparison with Group 2. Comparison included clinical manifestations, laboratory findings, serum gastrin, ultrasound findings, and endoscopic findings (esophageal and/or gastric varices and gastropathy). RESULTS: The percentage of GAVE in HCV‐related liver cirrhosis is 0.06%. We can predict GAVE by platelets, palmer erythema, diabetes mellitus (DM), marked ascites > with area under the curve of 0.67, 75.5, 0.62, and 0.40%, and accuracy of 82.5, 72, 70.7, and 79.3%, respectively. There was no correlation found between occurrence of GAVE and endoscopic findings. Also, there was no correlation found between occurrence of GAVE and serum gastrin levels, which reflect another pathophysiology, and we found no statistically significant correlation with GAVE. CONCLUSIONS: Palmer erythema, low platelets, DM, and ascites might help in the prediction of GAVE. GAVE is not linked to the presence, type or grade of varices, and gastropathy. Wiley Publishing Asia Pty Ltd 2021-07-06 /pmc/articles/PMC8341197/ /pubmed/34386601 http://dx.doi.org/10.1002/jgh3.12607 Text en © 2021 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Fouad, Magdy Khalaf Fath‐Elbab, Hanaa Mostafa, Alaa Mohamed Moness, Hend M Adel, Nashwa Mohamed Ahmed, Elham Gastric antral vascular ectasia in hepatitis C virus related liver cirrhosis: Fetching for predictors |
title | Gastric antral vascular ectasia in hepatitis C virus related liver cirrhosis: Fetching for predictors |
title_full | Gastric antral vascular ectasia in hepatitis C virus related liver cirrhosis: Fetching for predictors |
title_fullStr | Gastric antral vascular ectasia in hepatitis C virus related liver cirrhosis: Fetching for predictors |
title_full_unstemmed | Gastric antral vascular ectasia in hepatitis C virus related liver cirrhosis: Fetching for predictors |
title_short | Gastric antral vascular ectasia in hepatitis C virus related liver cirrhosis: Fetching for predictors |
title_sort | gastric antral vascular ectasia in hepatitis c virus related liver cirrhosis: fetching for predictors |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341197/ https://www.ncbi.nlm.nih.gov/pubmed/34386601 http://dx.doi.org/10.1002/jgh3.12607 |
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