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Efficacy of water-based vitamin E solution versus placebo in the prevention of retinopathy of prematurity in very low birth weight infants: A randomized clinical trial

BACKGROUND: Vitamin E has antioxidant properties, which help in scavenging free radicals, thereby reducing oxidation of lipids and proteins. This study aims to evaluate the efficacy of oral vitamin E supplementation in preventing retinopathy of prematurity (ROP) in very low birth weight (VLBW) infan...

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Autores principales: Romero-Maldonado, Silvia, Montoya-Estrada, Araceli, Reyes-Muñoz, Enrique, Guzmán-Grenfell, Alberto Martín, Torres-Ramos, Yessica Dorin, Sánchez-Mendez, Mario David, Tolentino-Dolores, Maricruz, Salgado-Valladares, Manuel Bernardo, Belmont-Gómez, Aurora, Najéra, Nayelli, Ceballos, Guillermo, Cardona-Pérez, Jorge Arturo, Hicks, Juan José, Mancilla-Ramírez, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341298/
https://www.ncbi.nlm.nih.gov/pubmed/34397821
http://dx.doi.org/10.1097/MD.0000000000026765
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author Romero-Maldonado, Silvia
Montoya-Estrada, Araceli
Reyes-Muñoz, Enrique
Guzmán-Grenfell, Alberto Martín
Torres-Ramos, Yessica Dorin
Sánchez-Mendez, Mario David
Tolentino-Dolores, Maricruz
Salgado-Valladares, Manuel Bernardo
Belmont-Gómez, Aurora
Najéra, Nayelli
Ceballos, Guillermo
Cardona-Pérez, Jorge Arturo
Hicks, Juan José
Mancilla-Ramírez, Javier
author_facet Romero-Maldonado, Silvia
Montoya-Estrada, Araceli
Reyes-Muñoz, Enrique
Guzmán-Grenfell, Alberto Martín
Torres-Ramos, Yessica Dorin
Sánchez-Mendez, Mario David
Tolentino-Dolores, Maricruz
Salgado-Valladares, Manuel Bernardo
Belmont-Gómez, Aurora
Najéra, Nayelli
Ceballos, Guillermo
Cardona-Pérez, Jorge Arturo
Hicks, Juan José
Mancilla-Ramírez, Javier
author_sort Romero-Maldonado, Silvia
collection PubMed
description BACKGROUND: Vitamin E has antioxidant properties, which help in scavenging free radicals, thereby reducing oxidation of lipids and proteins. This study aims to evaluate the efficacy of oral vitamin E supplementation in preventing retinopathy of prematurity (ROP) in very low birth weight (VLBW) infants with respiratory distress syndrome (RDS) and decreasing oxidative stress 15 and 28 days post-intervention. METHODS: Ninety VLBW infants were randomly assigned to two groups: 1. Treatment (treatment group (T), n = 48) or 2. Placebo (control group (C), n = 42). Each group received 25 IU of vitamin E (T) or placebo (C). RESULTS: The incidence of ROP in groups T and C was 12.5% (n=6) and 31% (n = 13), respectively (RR: 0.40; 95% CI: 0.10–0.96). There were no differences in mortality between groups. As expected, the vitamin E concentration was significantly increased 28 days post-intervention in group T. CONCLUSION: Oral supplementation with vitamin E may effectively prevent ROP development in VLBW infants with RDS. Oxidative damage markers were significantly lower, whereas total antioxidant capacity was increased in group T. However, levels of other antioxidants as vitamin A and C were not measured in two groups.
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spelling pubmed-83412982021-08-07 Efficacy of water-based vitamin E solution versus placebo in the prevention of retinopathy of prematurity in very low birth weight infants: A randomized clinical trial Romero-Maldonado, Silvia Montoya-Estrada, Araceli Reyes-Muñoz, Enrique Guzmán-Grenfell, Alberto Martín Torres-Ramos, Yessica Dorin Sánchez-Mendez, Mario David Tolentino-Dolores, Maricruz Salgado-Valladares, Manuel Bernardo Belmont-Gómez, Aurora Najéra, Nayelli Ceballos, Guillermo Cardona-Pérez, Jorge Arturo Hicks, Juan José Mancilla-Ramírez, Javier Medicine (Baltimore) 6200 BACKGROUND: Vitamin E has antioxidant properties, which help in scavenging free radicals, thereby reducing oxidation of lipids and proteins. This study aims to evaluate the efficacy of oral vitamin E supplementation in preventing retinopathy of prematurity (ROP) in very low birth weight (VLBW) infants with respiratory distress syndrome (RDS) and decreasing oxidative stress 15 and 28 days post-intervention. METHODS: Ninety VLBW infants were randomly assigned to two groups: 1. Treatment (treatment group (T), n = 48) or 2. Placebo (control group (C), n = 42). Each group received 25 IU of vitamin E (T) or placebo (C). RESULTS: The incidence of ROP in groups T and C was 12.5% (n=6) and 31% (n = 13), respectively (RR: 0.40; 95% CI: 0.10–0.96). There were no differences in mortality between groups. As expected, the vitamin E concentration was significantly increased 28 days post-intervention in group T. CONCLUSION: Oral supplementation with vitamin E may effectively prevent ROP development in VLBW infants with RDS. Oxidative damage markers were significantly lower, whereas total antioxidant capacity was increased in group T. However, levels of other antioxidants as vitamin A and C were not measured in two groups. Lippincott Williams & Wilkins 2021-08-06 /pmc/articles/PMC8341298/ /pubmed/34397821 http://dx.doi.org/10.1097/MD.0000000000026765 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 6200
Romero-Maldonado, Silvia
Montoya-Estrada, Araceli
Reyes-Muñoz, Enrique
Guzmán-Grenfell, Alberto Martín
Torres-Ramos, Yessica Dorin
Sánchez-Mendez, Mario David
Tolentino-Dolores, Maricruz
Salgado-Valladares, Manuel Bernardo
Belmont-Gómez, Aurora
Najéra, Nayelli
Ceballos, Guillermo
Cardona-Pérez, Jorge Arturo
Hicks, Juan José
Mancilla-Ramírez, Javier
Efficacy of water-based vitamin E solution versus placebo in the prevention of retinopathy of prematurity in very low birth weight infants: A randomized clinical trial
title Efficacy of water-based vitamin E solution versus placebo in the prevention of retinopathy of prematurity in very low birth weight infants: A randomized clinical trial
title_full Efficacy of water-based vitamin E solution versus placebo in the prevention of retinopathy of prematurity in very low birth weight infants: A randomized clinical trial
title_fullStr Efficacy of water-based vitamin E solution versus placebo in the prevention of retinopathy of prematurity in very low birth weight infants: A randomized clinical trial
title_full_unstemmed Efficacy of water-based vitamin E solution versus placebo in the prevention of retinopathy of prematurity in very low birth weight infants: A randomized clinical trial
title_short Efficacy of water-based vitamin E solution versus placebo in the prevention of retinopathy of prematurity in very low birth weight infants: A randomized clinical trial
title_sort efficacy of water-based vitamin e solution versus placebo in the prevention of retinopathy of prematurity in very low birth weight infants: a randomized clinical trial
topic 6200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341298/
https://www.ncbi.nlm.nih.gov/pubmed/34397821
http://dx.doi.org/10.1097/MD.0000000000026765
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