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Over-expression of vitronectin correlates with impaired survival in gastric cancers

Over-expression of vitronectin (VN) is associated with tumorigenesis. The present study aimed to evaluate the prognostic value of VN expression in gastric cancer. The least absolute shrinkage and selection operator analysis was performed to screen the hub gene from The Cancer Genome Atlas gastric ca...

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Autores principales: Gong, Chao, Hong, Haifeng, Xie, Jingfeng, Xue, Yuqin, Huang, Yudian, Zhang, Dekun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341310/
https://www.ncbi.nlm.nih.gov/pubmed/34397822
http://dx.doi.org/10.1097/MD.0000000000026766
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author Gong, Chao
Hong, Haifeng
Xie, Jingfeng
Xue, Yuqin
Huang, Yudian
Zhang, Dekun
author_facet Gong, Chao
Hong, Haifeng
Xie, Jingfeng
Xue, Yuqin
Huang, Yudian
Zhang, Dekun
author_sort Gong, Chao
collection PubMed
description Over-expression of vitronectin (VN) is associated with tumorigenesis. The present study aimed to evaluate the prognostic value of VN expression in gastric cancer. The least absolute shrinkage and selection operator analysis was performed to screen the hub gene from The Cancer Genome Atlas gastric cancer patients with complete follow-up data, and 347 patients were finally included. Moreover, 102 patients were enrolled from the Affiliated Fuzhou First Hospital of Fujian Medical University. VN expression in paired gastric cancer and adjacent gastric normal tissues was detected using immunohistochemistry, and the clinicopathological significance of VN expression was evaluated. The prognostic significance of VN expression in gastric cancer patients was evaluated using by Kaplan–Meier method and Cox regression analysis and confirmed using Oncomine. VN was the prognosis relative gene which screened by The Cancer Genome Atlas dataset. Moreover, we identified the VN expression in an external dataset by immunohistochemistry. The result demonstrated that VN expression was remarkedly elevated in gastric cancer tissues (P < .001). High VN expression correlated with higher pathological Tumor-Node-Metastasis stage, and poorer survival outcomes. Cox regression analysis showed that VN expression was independently predictive of overall survival (OS) and disease-free survival (P = .004, P < .001, respectively). A prognostic risk score for OS was built based on VN expression. A meta-analysis from Oncomine datasets revealed that significantly lower VN mRNA levels in gastric cancer correlated with poorer OS. VN expression could be a prognostic marker of gastric cancer.
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spelling pubmed-83413102021-08-07 Over-expression of vitronectin correlates with impaired survival in gastric cancers Gong, Chao Hong, Haifeng Xie, Jingfeng Xue, Yuqin Huang, Yudian Zhang, Dekun Medicine (Baltimore) 4500 Over-expression of vitronectin (VN) is associated with tumorigenesis. The present study aimed to evaluate the prognostic value of VN expression in gastric cancer. The least absolute shrinkage and selection operator analysis was performed to screen the hub gene from The Cancer Genome Atlas gastric cancer patients with complete follow-up data, and 347 patients were finally included. Moreover, 102 patients were enrolled from the Affiliated Fuzhou First Hospital of Fujian Medical University. VN expression in paired gastric cancer and adjacent gastric normal tissues was detected using immunohistochemistry, and the clinicopathological significance of VN expression was evaluated. The prognostic significance of VN expression in gastric cancer patients was evaluated using by Kaplan–Meier method and Cox regression analysis and confirmed using Oncomine. VN was the prognosis relative gene which screened by The Cancer Genome Atlas dataset. Moreover, we identified the VN expression in an external dataset by immunohistochemistry. The result demonstrated that VN expression was remarkedly elevated in gastric cancer tissues (P < .001). High VN expression correlated with higher pathological Tumor-Node-Metastasis stage, and poorer survival outcomes. Cox regression analysis showed that VN expression was independently predictive of overall survival (OS) and disease-free survival (P = .004, P < .001, respectively). A prognostic risk score for OS was built based on VN expression. A meta-analysis from Oncomine datasets revealed that significantly lower VN mRNA levels in gastric cancer correlated with poorer OS. VN expression could be a prognostic marker of gastric cancer. Lippincott Williams & Wilkins 2021-08-06 /pmc/articles/PMC8341310/ /pubmed/34397822 http://dx.doi.org/10.1097/MD.0000000000026766 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 4500
Gong, Chao
Hong, Haifeng
Xie, Jingfeng
Xue, Yuqin
Huang, Yudian
Zhang, Dekun
Over-expression of vitronectin correlates with impaired survival in gastric cancers
title Over-expression of vitronectin correlates with impaired survival in gastric cancers
title_full Over-expression of vitronectin correlates with impaired survival in gastric cancers
title_fullStr Over-expression of vitronectin correlates with impaired survival in gastric cancers
title_full_unstemmed Over-expression of vitronectin correlates with impaired survival in gastric cancers
title_short Over-expression of vitronectin correlates with impaired survival in gastric cancers
title_sort over-expression of vitronectin correlates with impaired survival in gastric cancers
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341310/
https://www.ncbi.nlm.nih.gov/pubmed/34397822
http://dx.doi.org/10.1097/MD.0000000000026766
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