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Estimation of stroke severity with National Institutes of Health Stroke Scale grading and retinal features: A cross-sectional study
To estimate National Institutes of Health Stroke Scale (NIHSS) grading of stroke patients with retinal characteristics. A cross-sectional study was conducted in Shenzhen Traditional Chinese Medicine Hospital. Baseline information and retinal photos were collected within 2 weeks of admission. An NIHS...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341321/ https://www.ncbi.nlm.nih.gov/pubmed/34397858 http://dx.doi.org/10.1097/MD.0000000000026846 |
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author | Zhuo, Yuanyuan Qu, Yimin Wu, Jiaman Huang, Xingxian Yuan, Weiqu Lee, Jack Yang, Zhuoxin Zee, Benny |
author_facet | Zhuo, Yuanyuan Qu, Yimin Wu, Jiaman Huang, Xingxian Yuan, Weiqu Lee, Jack Yang, Zhuoxin Zee, Benny |
author_sort | Zhuo, Yuanyuan |
collection | PubMed |
description | To estimate National Institutes of Health Stroke Scale (NIHSS) grading of stroke patients with retinal characteristics. A cross-sectional study was conducted in Shenzhen Traditional Chinese Medicine Hospital. Baseline information and retinal photos were collected within 2 weeks of admission. An NIHSS score was measured for each patient by trained doctors. Patients were classified into 0 to 4 score group and 5 to 42 score group for analysis. Three multivariate logistic models, with traditional clinical characteristics alone, with retinal characteristics alone, and with both, were built. For clinical characteristics, hypertension duration is statistically significantly associated with higher NIHSS score (P = .014). Elevated total homocysteine levels had an OR of 0.456 (P = .029). For retinal characteristics, the fractal dimension of the arteriolar network had an OR of 0.245 (P < .001) for the left eyes, and an OR of 0.417 (P = .009) for right eyes. The bifurcation coefficient of the arteriole of the left eyes had an OR of 2.931 (95% CI 1.573–5.46, P = .001), the nipping of the right eyes had an OR of 0.092 (P = .003) showed statistical significance in the model. The area under receiver-operating characteristic curve increased from 0.673, based on the model with clinical characteristics alone, to 0.896 for the model with retinal characteristics alone and increased to 0.931 for the model with both clinical and retinal characteristics combined. Retinal characteristics provided more information than clinical characteristics in estimating NIHSS grading and can provide us with an objective method for stroke severity estimation. |
format | Online Article Text |
id | pubmed-8341321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-83413212021-08-07 Estimation of stroke severity with National Institutes of Health Stroke Scale grading and retinal features: A cross-sectional study Zhuo, Yuanyuan Qu, Yimin Wu, Jiaman Huang, Xingxian Yuan, Weiqu Lee, Jack Yang, Zhuoxin Zee, Benny Medicine (Baltimore) 5300 To estimate National Institutes of Health Stroke Scale (NIHSS) grading of stroke patients with retinal characteristics. A cross-sectional study was conducted in Shenzhen Traditional Chinese Medicine Hospital. Baseline information and retinal photos were collected within 2 weeks of admission. An NIHSS score was measured for each patient by trained doctors. Patients were classified into 0 to 4 score group and 5 to 42 score group for analysis. Three multivariate logistic models, with traditional clinical characteristics alone, with retinal characteristics alone, and with both, were built. For clinical characteristics, hypertension duration is statistically significantly associated with higher NIHSS score (P = .014). Elevated total homocysteine levels had an OR of 0.456 (P = .029). For retinal characteristics, the fractal dimension of the arteriolar network had an OR of 0.245 (P < .001) for the left eyes, and an OR of 0.417 (P = .009) for right eyes. The bifurcation coefficient of the arteriole of the left eyes had an OR of 2.931 (95% CI 1.573–5.46, P = .001), the nipping of the right eyes had an OR of 0.092 (P = .003) showed statistical significance in the model. The area under receiver-operating characteristic curve increased from 0.673, based on the model with clinical characteristics alone, to 0.896 for the model with retinal characteristics alone and increased to 0.931 for the model with both clinical and retinal characteristics combined. Retinal characteristics provided more information than clinical characteristics in estimating NIHSS grading and can provide us with an objective method for stroke severity estimation. Lippincott Williams & Wilkins 2021-08-06 /pmc/articles/PMC8341321/ /pubmed/34397858 http://dx.doi.org/10.1097/MD.0000000000026846 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | 5300 Zhuo, Yuanyuan Qu, Yimin Wu, Jiaman Huang, Xingxian Yuan, Weiqu Lee, Jack Yang, Zhuoxin Zee, Benny Estimation of stroke severity with National Institutes of Health Stroke Scale grading and retinal features: A cross-sectional study |
title | Estimation of stroke severity with National Institutes of Health Stroke Scale grading and retinal features: A cross-sectional study |
title_full | Estimation of stroke severity with National Institutes of Health Stroke Scale grading and retinal features: A cross-sectional study |
title_fullStr | Estimation of stroke severity with National Institutes of Health Stroke Scale grading and retinal features: A cross-sectional study |
title_full_unstemmed | Estimation of stroke severity with National Institutes of Health Stroke Scale grading and retinal features: A cross-sectional study |
title_short | Estimation of stroke severity with National Institutes of Health Stroke Scale grading and retinal features: A cross-sectional study |
title_sort | estimation of stroke severity with national institutes of health stroke scale grading and retinal features: a cross-sectional study |
topic | 5300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341321/ https://www.ncbi.nlm.nih.gov/pubmed/34397858 http://dx.doi.org/10.1097/MD.0000000000026846 |
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